| Gene Symbol |
ACAN
|
| Entrez Gene |
176
|
| Alt Symbol |
AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aggrecan
|
| Other Description |
aggrecan core protein|cartilage-specific proteoglycan core protein|chondroitin sulfate proteoglycan core protein 1|large aggregating proteoglycan
|
| Swissprots |
P16112 Q13650 Q9UCD3 Q9UCP4 Q9UCP5 Q9UDE0
|
| Accessions |
AAB48068 AAC60643 AAD14782 AAD14783 AAD14784 AAD14785 AAD14786 AAD14788 AAD14789 AAD14791 AAD14792 AAD14793 AAD14794 AAD14795 AAD14796 AAD14797 AAD14798 AAD14799 AAD14800 AAD14801 AAD14802 AAD14804 AAD14805 AAD14806 AAD14807 AAD14808 AAD14809 AAD14810 AAD14811 AAD14812 AAD14814 AAD14815 AAD14816 CAI61688 EAX02017 EAX02018 EAX02019 EAX02020 EAX02021 P16112 AK290723 BAF83412 BC036445 AAH36445 BC150624 AAI50625 BQ182050 BQ446640 DA596050 J05062 AAA35726 L12234 M55172 AAA62824 U13192 X17406 CAA35463 X80278 XM_006720419 XP_006720482 XM_011521313 XP_011519615 XM_011521314 XP_011519616 NM_001135 NP_001126 NM_013227 NP_037359
|
| Function |
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Restricted to cartilages. {ECO:0000269|PubMed:7524681}.
|