| Gene Symbol |
pldB
|
| Entrez Gene |
8622060
|
| Alt Symbol |
DDBDRAFT_0205794, DDBDRAFT_0231507, DDB_0205794, DDB_0231507
|
| Species |
Dictyostelium discoideum
|
| Gene Type |
protein-coding
|
| Description |
phospholipase D1
|
| Other Description |
-
|
| Swissprots |
Q54WR4
|
| Accessions |
EAL67680 XM_636561 XP_641653
|
| Function |
Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization. Plays an important role in cell migration by localizing along the anterior cell membrane. Overexpression leads to the inability to aggregate even at higher cell density. Also known as a negative regulator of quorum sensing. {ECO:0000269|PubMed:15769249, ECO:0000269|PubMed:15821129, ECO:0000269|PubMed:6498208, ECO:0000269|PubMed:8394342}.
|
| Subcellular Location |
Cytoplasmic vesicle {ECO:0000269|PubMed:18164290}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18164290}. Note=In migrating cells, localized at the protruding regions of pseudopodia.
|
| Top Pathways |
Endocytosis, Ether lipid metabolism, Glycerophospholipid metabolism
|