| Gene Symbol |
icmA-2
|
| Entrez Gene |
8619243
|
| Alt Symbol |
DDBDRAFT_0217410, DDBDRAFT_0252724, DDB_0217410, DDB_0252724
|
| Species |
Dictyostelium discoideum
|
| Gene Type |
protein-coding
|
| Description |
prenylcysteine methyltransferase
|
| Other Description |
protein-S-isoprenylcysteine O-methyltransferase
|
| Swissprots |
Q86AM7 Q558K8 Q8T623
|
| Accessions |
XM_639264 XP_644356
|
| Function |
Methylates the C-terminal cysteine residues of small GTPases and the heterotrimeric G protein gamma subunit in response to cAMP. The methylation is required for intercellular signaling and regulation of cAMP waves propagation. It also seems to induce the activity of car1, a G protein-coupled receptor which senses extracellular cAMP during the aggregation phase of development. {ECO:0000269|PubMed:17699599}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Terpenoid backbone biosynthesis
|