Gene Symbol | SPCS1 |
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Entrez Gene | 28972 |
Alt Symbol | HSPC033, SPC1, SPC12, YJR010C-A |
Species | Human |
Gene Type | protein-coding |
Description | signal peptidase complex subunit 1 homolog (S. cerevisiae) |
Other Description | SPase 12 kDa subunit|microsomal signal peptidase 12 kDa subunit|signal peptidase 12kDa|signal peptidase complex subunit 1 |
Swissprots | Q9Y6A9 Q9BVW1 B3KNF8 |
Accessions | EAW65257 Q9Y6A9 AF092138 AAD40380 AK027426 BAG51320 AX775783 CAE11591 AX775785 CAE11592 AX775787 CAE11593 AX775833 CAE11616 BC000884 AAH00884 BG724036 BI826431 BQ423345 BU070128 CA309210 DB459917 L38852 AAL31361 NM_014041 NP_054760 |
Function | Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}. |
Subcellular Location | Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Protein export |
SPC12 CRISPR/Cas9 KO Plasmid (h) - sc-412011 from Santa Cruz Biotechnology
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SPC12 HDR Plasmid (h) - sc-412011-HDR from Santa Cruz Biotechnology
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SPC12 Double Nickase Plasmid (h) - sc-412011-NIC from Santa Cruz Biotechnology
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SPC12 Double Nickase Plasmid (h2) - sc-412011-NIC-2 from Santa Cruz Biotechnology
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SPC12 CRISPR Activation Plasmid (h) - sc-412011-ACT from Santa Cruz Biotechnology
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SPC12 CRISPR Activation Plasmid (h2) - sc-412011-ACT-2 from Santa Cruz Biotechnology
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SPC12 Lentiviral Activation Particles (h) - sc-412011-LAC from Santa Cruz Biotechnology
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SPC12 Lentiviral Activation Particles (h2) - sc-412011-LAC-2 from Santa Cruz Biotechnology
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SPC12 siRNA (h) - sc-78443 from Santa Cruz Biotechnology
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SPC12 shRNA Plasmid (h) - sc-78443-SH from Santa Cruz Biotechnology
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SPC12 shRNA (h) Lentiviral Particles - sc-78443-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU016491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20437 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20437 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03209 from Sigma-Aldrich
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SPCS1 siRNA (Human) - CRH9138 from Cohesion Biosciences
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SPCS1 - MBS8235184 from MyBioSource
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Human SPCS1 siRNA - orb269640 from Biorbyt
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SPCS1 shRNA Plasmid (Human) - CHH9138 from Cohesion Biosciences
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SPCS1 miRNA 3'UTR clone - MiUTR3H-11183 from Creative biogene
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