Gene Symbol | AASDHPPT |
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Entrez Gene | 60496 |
Alt Symbol | AASD-PPT, CGI-80, LYS2, LYS5 |
Species | Human |
Gene Type | protein-coding |
Description | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase |
Other Description | 4'-phosphopantetheinyl transferase|L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase|LYS5 ortholog|alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase |
Swissprots | B4DDW7 Q9UG80 Q9P0Q3 Q9C068 B2R6D1 Q9NRN7 Q9Y389 |
Accessions | EAW67077 EAW67078 Q9NRN7 AB072896 AF136978 AAG49439 AF151057 AAF36143 AF151838 AAD34075 AF201943 AAF86879 AF302110 AAG30872 AK293362 BAG56878 AK312529 BAG35428 AL050073 CAB43257 BC015470 AAH15470 BC016728 AAH16728 BX537665 DQ891342 ABM82268 DQ894524 ABM85450 NM_015423 NP_056238 |
Function | Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12815048}. |
Tissue Specificity | Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048}. |
Top Pathways | Pantothenate and CoA biosynthesis |
AASDHPPT CRISPR/Cas9 KO Plasmid (h) - sc-412940 from Santa Cruz Biotechnology
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AASDHPPT HDR Plasmid (h) - sc-412940-HDR from Santa Cruz Biotechnology
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AASDHPPT Double Nickase Plasmid (h) - sc-412940-NIC from Santa Cruz Biotechnology
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AASDHPPT Double Nickase Plasmid (h2) - sc-412940-NIC-2 from Santa Cruz Biotechnology
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AASDHPPT CRISPR Activation Plasmid (h) - sc-412940-ACT from Santa Cruz Biotechnology
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AASDHPPT CRISPR Activation Plasmid (h2) - sc-412940-ACT-2 from Santa Cruz Biotechnology
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AASDHPPT Lentiviral Activation Particles (h) - sc-412940-LAC from Santa Cruz Biotechnology
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AASDHPPT Lentiviral Activation Particles (h2) - sc-412940-LAC-2 from Santa Cruz Biotechnology
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AASDHPPT siRNA (h) - sc-96943 from Santa Cruz Biotechnology
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AASDHPPT shRNA Plasmid (h) - sc-96943-SH from Santa Cruz Biotechnology
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AASDHPPT shRNA (h) Lentiviral Particles - sc-96943-V from Santa Cruz Biotechnology
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AASD-PPT RNAi - H00060496-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2615 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2615 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10346 from Sigma-Aldrich
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AASDHPPT siRNA (Human) - CRJ1809 from Cohesion Biosciences
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AASDHPPT - MBS827414 from MyBioSource
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shRNA set against Human AASDHPPT (NM_015423.2) - SHH228694 from Creative biogene
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Human AASDHPPT siRNA - orb272310 from Biorbyt
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AASDHPPT shRNA Plasmid (Human) - CHJ1809 from Cohesion Biosciences
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AASDHPPT miRNA 3'UTR clone - MiUTR1H-00012 from Creative biogene
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