| Gene Symbol |
S100P
|
| Entrez Gene |
6286
|
| Alt Symbol |
MIG9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
S100 calcium binding protein P
|
| Other Description |
S100 calcium-binding protein P|migration-inducing gene 9 protein|protein S100-E|protein S100-P
|
| Swissprots |
Q5J7W2 P25815
|
| Accessions |
EAW82384 P25815 AF539739 AAO41114 AI202505 AY423724 AAS00487 BC006819 AAH06819 BI259919 BT007289 AAP35953 DQ891088 ABM82014 DQ894270 ABM85196 X65614 CAA46566 NM_005980 NP_005971
|
| Function |
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium- dependent manner.
|
| Tissue Specificity |
Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up- regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. {ECO:0000269|PubMed:14672411, ECO:0000269|PubMed:15632002}.
|