| Gene Symbol | TPMT |
|---|---|
| Entrez Gene | 7172 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | thiopurine S-methyltransferase |
| Other Description | S-adenosyl-L-methionine:thiopurine S-methyltransferase |
| Swissprots | Q9UBE6 O15515 P51580 O15423 O15548 Q9UBT8 O14806 O15426 O15424 O15425 Q9UE62 Q5VUK6 O43213 |
| Accessions | AAB71625 AAB71626 AAB71627 AAB71628 AAB71629 AAB71630 AAB71631 AAB71632 AAB71633 AAB71634 AAB71635 AAB71636 AAC32289 AAC50368 AAC51865 BAA97037 EAW55393 EAW55394 EAW55395 EAW55396 EAW55397 EAW55398 EAW55399 P51580 AA746081 AA825975 AF021876 AAB80746 AF021877 AAB80747 AK310420 BC005339 AAH05339 BC009596 AAH09596 BI598325 DB481604 HQ448729 ADQ33207 HY252883 HY300307 S62904 AAB27277 U12387 AAC50130 XM_011514839 XP_011513141 XM_011514840 XP_011513142 NM_000367 NP_000358 |
| Function | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. {ECO:0000269|PubMed:18484748}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Drug metabolism - other enzymes |