| Gene Symbol | Birc2 |
|---|---|
| Entrez Gene | 11797 |
| Alt Symbol | AW146227, Api1, Api2, Birc3, HIAP1, HIAP2, IAP1, IAP2, MIAP1, MIAP2, MIHB, MIHC, RNF48, cIAP1, cIAP2, mcIAP1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | baculoviral IAP repeat-containing 2 |
| Other Description | IAP-2|apoptosis inhibitor 2|baculoviral IAP repeat-containing 3|baculoviral IAP repeat-containing protein 2|inhibitor of apoptosis protein 2|mIAP-2 |
| Swissprots | O08864 Q62210 A6H6S7 |
| Accessions | EDL24945 Q62210 BC033480 BC145985 AAI45986 BX518872 DQ713513 L49433 AAC42078 U88909 AAC53532 XM_006509834 XP_006509897 XM_006509835 XP_006509898 XM_011242354 XP_011240656 NM_007465 NP_031491 |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptor |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. |
| Top Pathways | NOD-like receptor signaling pathway, TNF signaling pathway, Hippo signaling pathway, Toxoplasmosis, Apoptosis |