Gene Symbol | NRF1 |
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Entrez Gene | 4899 |
Alt Symbol | ALPHA-PAL |
Species | Human |
Gene Type | protein-coding |
Description | nuclear respiratory factor 1 |
Other Description | alpha palindromic-binding protein |
Swissprots | Q15305 B4DDV6 A8K4C6 Q96AN2 Q16656 |
Accessions | AAA79013 CBJ21209 EAL24100 EAW83726 EAW83727 EAW83728 EAW83729 EAW83730 EAW83731 Q16656 AI816827 AK290891 BAF83580 AK293351 BAG56867 AL530274 BC016925 AAH16925 BG742958 BM449724 BM993780 BP215381 DN998889 EU159452 ABV90872 EU446643 ABZ92172 HY166547 L22454 AAA16918 U02683 AAA21647 U44848 NM_001040110 NP_001035199 NM_001293163 NP_001280092 NM_001293164 NP_001280093 NM_005011 NP_005002 |
Function | Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. |
Subcellular Location | Nucleus. |
Tissue Specificity | Ubiquitously expressed with strongest expression in skeletal muscle. |
Top Pathways | Huntington's disease |
NRF-1 CRISPR/Cas9 KO Plasmid (h) - sc-400938 from Santa Cruz Biotechnology
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NRF-1 HDR Plasmid (h) - sc-400938-HDR from Santa Cruz Biotechnology
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NRF-1 Double Nickase Plasmid (h) - sc-400938-NIC from Santa Cruz Biotechnology
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NRF-1 Double Nickase Plasmid (h2) - sc-400938-NIC-2 from Santa Cruz Biotechnology
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NRF-1 CRISPR Activation Plasmid (h) - sc-400938-ACT from Santa Cruz Biotechnology
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NRF-1 CRISPR Activation Plasmid (h2) - sc-400938-ACT-2 from Santa Cruz Biotechnology
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NRF-1 Lentiviral Activation Particles (h) - sc-400938-LAC from Santa Cruz Biotechnology
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NRF-1 Lentiviral Activation Particles (h2) - sc-400938-LAC-2 from Santa Cruz Biotechnology
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NRF-1 siRNA (h) - sc-38105 from Santa Cruz Biotechnology
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NRF-1 shRNA Plasmid (h) - sc-38105-SH from Santa Cruz Biotechnology
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NRF-1 shRNA (h) Lentiviral Particles - sc-38105-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU069871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15507 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15507 from Sigma-Aldrich
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NRF1 siRNA (Human) - CRH3255 from Cohesion Biosciences
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shRNA set against Human NRF1 (NM_005011.3) - SHH355020 from Creative biogene
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shRNA set against Human NRF1(NM_001040110.1) - SHR021682 from Creative biogene
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shRNA set against Human NRF1(NM_005011.3) - SHR021808 from Creative biogene
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shRNA set against Human NRF1(NM_001040110.1) - SHR021824 from Creative biogene
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Human NRF1 siRNA - orb263757 from Biorbyt
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NRF1 shRNA Plasmid (Human) - CHH3255 from Cohesion Biosciences
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NRF1 miRNA 3'UTR clone - MiUTR1H-06919 from Creative biogene
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NRF1 miRNA 3'UTR clone - MiUTR1H-06920 from Creative biogene
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