| Gene Symbol |
Mcm4
|
| Entrez Gene |
17217
|
| Alt Symbol |
19G, AI325074, AU045576, Cdc21, Mcmd4, mKIAA4003, mcdc21
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
|
| Other Description |
CDC21 homolog|DNA replication licensing factor MCM4|P1-CDC21|mini chromosome maintenance deficient 4 homolog
|
| Swissprots |
P49717 O89056
|
| Accessions |
BAA34641 CBX85474 EDK97402 P49717 AK011743 BAB27813 AK036653 AK083618 AK088796 BAC40578 AK089999 BAC41036 AK135422 BAE22526 AK135619 BAE22594 AK141132 AK141644 BAE24783 AK146662 BAE27340 AK151499 BAE30450 AK157725 BAE34170 AK198832 AK199459 AK203349 AK204613 AK220442 BAD90271 BC013094 AAH13094 D26089 BAA05082 U89402 AAC36509 X67535 NM_008565 NP_032591
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
DNA replication, Cell cycle
|