Gene Symbol | KRT72 |
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Entrez Gene | 140807 |
Alt Symbol | K6IRS2, K6irs, KRT6, KRT6IRS2 |
Species | Human |
Gene Type | protein-coding |
Description | keratin 72, type II |
Other Description | CK-72|K72|cytokeratin-72|keratin 6, inner root sheath, 2|keratin protein K6irs|keratin, type II cytoskeletal 72|keratin-72|type II inner root sheath-specific keratin-K6irs2|type-II keratin Kb35 |
Swissprots | Q8NA87 Q14CN4 Q8WWY9 Q8WWZ0 B4DEI8 H9KV51 |
Accessions | AAK55109 CBH19338 EAW96638 EAW96639 Q14CN4 AK093060 BAC04039 AK293645 BAG57099 AK302016 BAG63416 AY033495 AAK55108 BC113686 AAI13687 BX089867 HQ258454 ADR83208 XM_011537941 XP_011536243 XM_011537942 XP_011536244 XM_011537943 XP_011536245 XM_011537944 XP_011536246 XM_011537945 XP_011536247 NM_001146225 NP_001139697 NM_001146226 NP_001139698 NM_080747 NP_542785 |
Function | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
Tissue Specificity | Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level). {ECO:0000269|PubMed:11703281, ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310}. |
Keratin 72 CRISPR/Cas9 KO Plasmid (h) - sc-414499 from Santa Cruz Biotechnology
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Keratin 72 HDR Plasmid (h) - sc-414499-HDR from Santa Cruz Biotechnology
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Keratin 72 Double Nickase Plasmid (h) - sc-414499-NIC from Santa Cruz Biotechnology
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Keratin 72 Double Nickase Plasmid (h2) - sc-414499-NIC-2 from Santa Cruz Biotechnology
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Keratin 72 CRISPR Activation Plasmid (h) - sc-414499-ACT from Santa Cruz Biotechnology
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Keratin 72 CRISPR Activation Plasmid (h2) - sc-414499-ACT-2 from Santa Cruz Biotechnology
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Keratin 72 Lentiviral Activation Particles (h) - sc-414499-LAC from Santa Cruz Biotechnology
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Keratin 72 Lentiviral Activation Particles (h2) - sc-414499-LAC-2 from Santa Cruz Biotechnology
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Keratin 72 siRNA (h) - sc-96192 from Santa Cruz Biotechnology
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Keratin 72 shRNA Plasmid (h) - sc-96192-SH from Santa Cruz Biotechnology
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Keratin 72 shRNA (h) Lentiviral Particles - sc-96192-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU119881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11397 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11397 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03365 from Sigma-Aldrich
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KRT72 siRNA (Human) - CRJ5324 from Cohesion Biosciences
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shRNA set against Human KRT72 (NM_080747.2) - SHH327635 from Creative biogene
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KRT72 shRNA Plasmid (Human) - CHJ5324 from Cohesion Biosciences
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KRT72 miRNA 3'UTR clone - MiUTR4H-TG04916 from Creative biogene
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