| Gene Symbol | Got2 |
|---|---|
| Entrez Gene | 14719 |
| Alt Symbol | AL022787, FABP-pm, Got-2, mAspAT |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glutamatic-oxaloacetic transaminase 2, mitochondrial |
| Other Description | FABP-1|FABPpm|aspartate aminotransferase, mitochondrial|fatty acid-binding protein|glutamate oxaloacetate transaminase 2, mitochondrial|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mitochondrial aspartate aminotransferase|plasma membrane fatty acid binding protein|plasma membrane-associated fatty acid-binding protein|transaminase A |
| Swissprots | Q3TIP6 P05202 Q3UD91 O09188 Q5HZH5 |
| Accessions | AAA37265 CAA30015 CBF96248 CBV09768 EDL11189 P05202 AK008031 AK098166 AK136556 BAE23042 AK147953 BAE28248 AK149886 BAE29146 AK149926 BAE29171 AK150194 BAE29370 AK152921 BAE31596 AK155075 BAE33029 AK167767 BAE39800 AK178520 AK188010 AK190359 AK197537 AK197703 AK197746 AK198689 AK204973 AK209529 AK212627 AK215239 AK219323 BC089015 AAH89015 BC089341 AAH89341 J02622 AAA37264 U82470 AAB91426 NM_010325 NP_034455 |
| Function | Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:20977429, ECO:0000269|PubMed:7878064}. |
| Subcellular Location | Mitochondrion matrix. Cell membrane. |
| Tissue Specificity | Detected in brain (at protein level). {ECO:0000269|PubMed:17442055}. |
| Top Pathways | Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism |