Gene Symbol | Got2 |
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Entrez Gene | 14719 |
Alt Symbol | AL022787, FABP-pm, Got-2, mAspAT |
Species | Mouse |
Gene Type | protein-coding |
Description | glutamatic-oxaloacetic transaminase 2, mitochondrial |
Other Description | FABP-1|FABPpm|aspartate aminotransferase, mitochondrial|fatty acid-binding protein|glutamate oxaloacetate transaminase 2, mitochondrial|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mitochondrial aspartate aminotransferase|plasma membrane fatty acid binding protein|plasma membrane-associated fatty acid-binding protein|transaminase A |
Swissprots | Q3TIP6 P05202 Q3UD91 O09188 Q5HZH5 |
Accessions | AAA37265 CAA30015 CBF96248 CBV09768 EDL11189 P05202 AK008031 AK098166 AK136556 BAE23042 AK147953 BAE28248 AK149886 BAE29146 AK149926 BAE29171 AK150194 BAE29370 AK152921 BAE31596 AK155075 BAE33029 AK167767 BAE39800 AK178520 AK188010 AK190359 AK197537 AK197703 AK197746 AK198689 AK204973 AK209529 AK212627 AK215239 AK219323 BC089015 AAH89015 BC089341 AAH89341 J02622 AAA37264 U82470 AAB91426 NM_010325 NP_034455 |
Function | Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:20977429, ECO:0000269|PubMed:7878064}. |
Subcellular Location | Mitochondrion matrix. Cell membrane. |
Tissue Specificity | Detected in brain (at protein level). {ECO:0000269|PubMed:17442055}. |
Top Pathways | Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism |
AATM CRISPR/Cas9 KO Plasmid (m) - sc-420628 from Santa Cruz Biotechnology
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AATM HDR Plasmid (m) - sc-420628-HDR from Santa Cruz Biotechnology
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AATM Double Nickase Plasmid (m) - sc-420628-NIC from Santa Cruz Biotechnology
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AATM Double Nickase Plasmid (m2) - sc-420628-NIC-2 from Santa Cruz Biotechnology
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AATM CRISPR Activation Plasmid (m) - sc-420628-ACT from Santa Cruz Biotechnology
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AATM CRISPR Activation Plasmid (m2) - sc-420628-ACT-2 from Santa Cruz Biotechnology
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AATM Lentiviral Activation Particles (m) - sc-420628-LAC from Santa Cruz Biotechnology
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AATM Lentiviral Activation Particles (m2) - sc-420628-LAC-2 from Santa Cruz Biotechnology
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AATM siRNA (m) - sc-60055 from Santa Cruz Biotechnology
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AATM shRNA Plasmid (m) - sc-60055-SH from Santa Cruz Biotechnology
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AATM shRNA (m) Lentiviral Particles - sc-60055-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU094111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32645 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32645 from Sigma-Aldrich
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GOT2 siRNA (Mouse) - CRM1635 from Cohesion Biosciences
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GOT2 - MBS827360 from MyBioSource
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shRNA set against Mouse GOT2 (NM_010325.2) - SHH305510 from Creative biogene
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shRNA set against Mouse Got2(NM_010325.2) - SHH094889 from Creative biogene
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Mouse GOT2 siRNA - orb281111 from Biorbyt
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GOT2 shRNA Plasmid (Mouse) - CHM1635 from Cohesion Biosciences
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GOT2 miRNA 3'UTR clone - MiUTR1M-05249 from Creative biogene
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