Gene Symbol | CFHR2 |
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Entrez Gene | 3080 |
Alt Symbol | CFHL2, FHR2, HFL3 |
Species | Human |
Gene Type | protein-coding |
Description | complement factor H-related 2 |
Other Description | DDESK59|FHR-2|H factor (complement)-like 3|complement factor H-related protein 2|factor H-related gene 2|h factor-like 3|h factor-like protein 2 |
Swissprots | Q5T9T1 Q14310 P36980 |
Accessions | CAA60375 CBN73474 EAW91267 P36980 AX772812 CAE06255 BC022283 AAH22283 BG566607 DQ891405 ABM82331 DQ894582 ABM85508 X64877 CAA46096 XM_005245113 XP_005245170 XM_006711285 XP_006711348 XM_011509458 XP_011507760 XM_011509459 XP_011507761 XM_011509460 XP_011507762 XM_011509461 XP_011507763 NM_005666 NP_005657 |
Function | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269|PubMed:23487775}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed by the liver and secreted in plasma. |
FHR-2 CRISPR/Cas9 KO Plasmid (h) - sc-418402 from Santa Cruz Biotechnology
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FHR-2 HDR Plasmid (h) - sc-418402-HDR from Santa Cruz Biotechnology
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FHR-2 Double Nickase Plasmid (h) - sc-418402-NIC from Santa Cruz Biotechnology
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FHR-2 Double Nickase Plasmid (h2) - sc-418402-NIC-2 from Santa Cruz Biotechnology
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FHR-2 CRISPR Activation Plasmid (h) - sc-418402-ACT from Santa Cruz Biotechnology
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FHR-2 CRISPR Activation Plasmid (h2) - sc-418402-ACT-2 from Santa Cruz Biotechnology
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FHR-2 Lentiviral Activation Particles (h) - sc-418402-LAC from Santa Cruz Biotechnology
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FHR-2 Lentiviral Activation Particles (h2) - sc-418402-LAC-2 from Santa Cruz Biotechnology
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FHR-2 siRNA (h) - sc-88699 from Santa Cruz Biotechnology
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FHR-2 shRNA Plasmid (h) - sc-88699-SH from Santa Cruz Biotechnology
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FHR-2 shRNA (h) Lentiviral Particles - sc-88699-V from Santa Cruz Biotechnology
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Complement Factor H-related 2/CFHR2/CFHL2 RNAi - H00003080-R01 from Novus Biologicals
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MISSION® esiRNA - EHU104841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6001 from Sigma-Aldrich
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CFHR2 siRNA (Human) - CRH2098 from Cohesion Biosciences
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CFHR2 - MBS8224028 from MyBioSource
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shRNA set against Human CFHR2 (NM_005666.2) - SHH262441 from Creative biogene
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CFHR2 shRNA Plasmid (Human) - CHH2098 from Cohesion Biosciences
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CFHR2 miRNA 3'UTR clone - MiUTR1H-02074 from Creative biogene
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