PPP1CC

Gene Symbol	PPP1CC
Entrez Gene	5501
Alt Symbol	PP-1G, PP1C, PPP1G
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, gamma isozyme
Other Description	protein phosphatase 1, catalytic subunit, gamma isoform\|protein phosphatase 1C catalytic subunit\|serine/threonine phosphatase 1 gamma\|serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Swissprots	P36873
Accessions	BAA82664 EAW97938 EAW97939 EAW97940 P36873 AA781342 AK091841 AK297882 BAG60205 AW575661 BC014073 AAH14073 DA472620 DA514523 EU831993 ACE87434 EU832086 ACE86748 JF432841 ADZ16058 L07395 AAA19823 X74008 CAA52169 XM_011538504 XP_011536806 XM_011538505 XP_011536807 NM_001244974 NP_001231903 NM_002710 NP_002701
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. {ECO:0000250}.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

PP1γ (C-19) - sc-6108 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Western blot analysis of PP1γ expression in T-47D (A,E), SK-BR-3 (B,F), CTLL-2 (C,G) and WEHI-231 (D,H) whole cell lysates. Antibodies tested include PP1γ (C-19): sc-6108 (A-D) and PP1γ (N-19): sc-6109 (E-H).

PP1γ (N-19) - sc-6109 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

PP1γ (N-19): sc-6109. Western blot analysis of PP1γ expression in whole cell lysates of human breast cancer-derived cell lines T-47D (A), SK-BR-3 (B) and BT-20 (C).

Anti-PP1C gamma antibody - ab33622 from Abcam

Prices	$370.00
Sizes	250 µg
Host	Chicken
Clonality	Polyclonal

Anti-Protein phosphatase 1 gamma 2 antibody - ab130626 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Protein phosphatase 1 gamma 2 antibody (ab130626) at 1/100 dilution + WiDr cell line lysates at 35 µg

Anti-Protein phosphatase 1 gamma 2 antibody - ab33634 from Abcam

Prices	$370.00
Sizes	200 µg
Host	Chicken
Clonality	Polyclonal

Anti-Protein phosphatase 1 gamma 2 antibody [EPR8934] - ab134947 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8934

All lanes : Anti-Protein phosphatase 1 gamma 2 antibody [EPR8934] (ab134947) at 1/1000 dilutionLane 1 : T47D cell lysateLane 2 : 293T cell lysateLane 3 : SKBR3 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-PPP1CC / PP1 Gamma Antibody (C-Terminus) - LS-C287745 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human PPP1CC by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PPP1CC used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-PPP1CC / PP1 Gamma Antibody (C-Terminus) - LS-C286701 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (aa281-309) - LS-C162077 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of PPP1CC (arrow) using rabbit polyclonal PPP1CC Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PPP1CC gene.

Anti-PPP1CC / PP1 Gamma Antibody (aa2-227) - LS-C185715 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded SAS xenograft using PPP1CC antibody at 1:100 dilution.

Anti-PPP1CC / PP1 Gamma Antibody - LS-C26536 from LifeSpan Bioscience

Prices	$330.00
Sizes	100 µg
Host	Sheep
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody - LS-C38580 from LifeSpan Bioscience

Prices	$325.00
Sizes	200 µg
Host	Chicken
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (aa280-309, AP) - LS-C266893 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (aa280-309, APC) - LS-C266894 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (aa280-309, Biotin) - LS-C266896 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (aa280-309, FITC) - LS-C266897 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (C-Terminus) - LS-C151785 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

PPP1CC / PP1 Gamma antibody Western Blot of HeLa.

Anti-PPP1CC / PP1 Gamma Antibody (aa280-309, Azide-free, HRP) - LS-C266899 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (aa291-321) - LS-C101011 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of hPPP1CC-A306 in HeLa, T47D cell line lysates (35 ug/lane). PPP1CC (arrow) was detected using the purified antibody.

Anti-PPP1CC / PP1 Gamma Antibody (C-Terminus, clone EPR8934) - LS-C154721 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8934

Western blot analysis on (A) T47-D, (B) 293T, (C) SKBR-3, and (D) HeLa cell lysates using anti-PPP1CC antibody.

Anti-PPP1CC / PP1 Gamma Antibody (aa280-309, PE) - LS-C266900 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (N-Terminus, AP) - LS-C281492 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (N-Terminus, APC) - LS-C281494 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (N-Terminus, FITC) - LS-C281496 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PPP1CC / PP1 Gamma Antibody (N-Terminus, Biotin) - LS-C281495 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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