| Gene Symbol |
Herc2
|
| Entrez Gene |
15204
|
| Alt Symbol |
D15F32S1h, D7H15F32S1, D7H15F37S1, jdf2, mKIAA0393, rjs
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
|
| Other Description |
E3 ubiquitin-protein ligase HERC2|HECT domain and RCC1-like domain-containing protein 2|herc2|probable E3 ubiquitin-protein ligase HERC2
|
| Swissprots |
Q4U2R1 Q5DU32 E9PZT6 Q3TST2 Q9QYT1 Q80VV7 O88473 Q3URH7 Q9Z168 Q7TPR5 Q9Z171 Q3TS47 Q3TRJ8 Q3UFQ6
|
| Accessions |
AAD08659 AAD08660 AAD08661 EDL21868 EDL21869 Q4U2R1 AF061529 AAC31431 AF061530 AAC31432 AF061531 AAC31433 AF061532 AAC31434 AF071173 AAD08658 AK140430 AK141515 BAE24711 AK148361 BAE28504 AK161826 BAE36593 AK162270 BAE36828 AK162708 BAE37031 AK165121 AK216874 AK220338 BAD90404 BC044667 AAH44667 BC054829 AAH54829 BP754028 BY241058 XM_006540637 XP_006540700 XM_006540638 XP_006540701 XM_006540639 XP_006540702 NM_010418 NP_034548
|
| Function |
E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Nucleus {ECO:0000250}. Note=Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis. {ECO:0000250}.
|
| Tissue Specificity |
Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen. {ECO:0000269|PubMed:9689098}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|