| Gene Symbol |
IL18R1
|
| Entrez Gene |
8809
|
| Alt Symbol |
CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 18 receptor 1
|
| Other Description |
CD218 antigen-like family member A|IL-18R-1|IL-18R1|IL1 receptor-related protein|IL18Ralpha2|IL1R-rp|cytokine receptor|interleukin-18 receptor 1
|
| Swissprots |
Q13478 Q52LC9 B2R9Y5
|
| Accessions |
AAY15048 EAX01792 EAX01793 EAX01794 Q13478 AI803942 AY192162 AAO41718 BC069575 AAH69575 BC093975 AAH93975 BC093977 AAH93977 BC143403 AAI43404 BC143405 DR006178 KM264374 AIR76260 KM264375 AIR76261 U43672 AAC50390 XM_005264039 XP_005264096 XM_005264040 XP_005264097 XM_006712823 XP_006712886 XM_011512099 XP_011510401 XR_923054 NM_001282399 NP_001269328 NM_003855 NP_003846
|
| Function |
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, TNF signaling pathway, Inflammatory bowel disease (IBD)
|