SMARCE1
| Gene Symbol | SMARCE1 |
|---|---|
| Entrez Gene | 6605 |
| Alt Symbol | BAF57 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
| Other Description | BRG1-associated factor 57|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1|chromatin remodeling complex BRG1-associated factor 57 |
| Swissprots | C0IMW7 Q969G3 O43539 B4DFR4 C0IMW4 C0IMW5 H7C3F6 B3KMC1 |
| Accessions | AAC04509 EAW60670 EAW60671 Q969G3 AK001532 BAG50933 AK023653 AK095047 BAG52975 AK294218 BAG57525 AK294666 BAG57834 BC007082 AAH07082 BC011017 AAH11017 BC047731 BC063700 AAH63700 BC069196 BQ707908 BT007176 AAP35840 DQ890712 ABM81638 DQ893481 ABM84407 DQ893894 ABM84820 DQ896382 ABM87381 EU327017 ACA81391 EU327018 ACA81392 EU327019 ACA81393 EU327020 ACA81394 EU327021 ACA81395 NM_003079 NP_003070 |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neur |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:12192000}. |
BAF57 CRISPR/Cas9 KO Plasmid (h) - sc-404713 from Santa Cruz Biotechnology
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BAF57 HDR Plasmid (h) - sc-404713-HDR from Santa Cruz Biotechnology
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BAF57 Double Nickase Plasmid (h) - sc-404713-NIC from Santa Cruz Biotechnology
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BAF57 Double Nickase Plasmid (h2) - sc-404713-NIC-2 from Santa Cruz Biotechnology
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BAF57 CRISPR Activation Plasmid (h) - sc-404713-ACT from Santa Cruz Biotechnology
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BAF57 CRISPR Activation Plasmid (h2) - sc-404713-ACT-2 from Santa Cruz Biotechnology
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BAF57 Lentiviral Activation Particles (h) - sc-404713-LAC from Santa Cruz Biotechnology
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BAF57 Lentiviral Activation Particles (h2) - sc-404713-LAC-2 from Santa Cruz Biotechnology
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BAF57 siRNA (h) - sc-45940 from Santa Cruz Biotechnology
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BAF57 shRNA Plasmid (h) - sc-45940-SH from Santa Cruz Biotechnology
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BAF57 shRNA (h) Lentiviral Particles - sc-45940-V from Santa Cruz Biotechnology
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BAF57 RNAi - H00006605-R01 from Novus Biologicals
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MISSION® esiRNA - EHU146881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19772 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19772 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07851 from Sigma-Aldrich
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SMARCE1 siRNA (Human) - CRH4488 from Cohesion Biosciences
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SMARCE1 - MBS8234937 from MyBioSource
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shRNA set against Human SMARCE1 (NM_003079.4) - SHH413216 from Creative biogene
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Human SMARCE1 siRNA - orb264990 from Biorbyt
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SMARCE1 shRNA Plasmid (Human) - CHH4488 from Cohesion Biosciences
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SMARCE1 miRNA 3'UTR clone - MiUTR1H-09651 from Creative biogene
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