| Gene Symbol |
Kdm6b
|
| Entrez Gene |
216850
|
| Alt Symbol |
1700064E03Rik, BC038313, Jmjd3, mKIAA0346
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
KDM1 lysine (K)-specific demethylase 6B
|
| Other Description |
jmjC domain-containing protein 3|jumonji domain containing 3|jumonji domain-containing protein 3|lysine-specific demethylase 6B
|
| Swissprots |
Q3UWY9 Q4VC26 Q6ZQD3 Q5NCY0
|
| Accessions |
EDL10500 Q5NCY0 AK129121 BAC97931 AK134236 AK136019 BAE22775 AK142488 BAE25082 BC029201 AAH29201 BC038313 BC075632 AAH75632 CA945559 XM_006532898 XP_006532961 XM_011248919 XP_011247221 XM_011248920 XP_011247222 XM_011248921 XP_011247223 XM_011248922 XP_011247224 XM_011248923 XP_011247225 NM_001017426 NP_001017426
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. {ECO:0000269|PubMed:17825402}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|