Gene Symbol | DUSP16 |
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Entrez Gene | 80824 |
Alt Symbol | MKP-7, MKP7 |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 16 |
Other Description | MAP kinase phosphatase 7|MAPK phosphatase-7|dual specificity protein phosphatase 16|mitogen-activated protein kinase phosphatase 7 |
Swissprots | Q96QS2 Q547C7 Q9BY84 Q9C0G3 |
Accessions | CAD10218 CAD10545 CAD34807 EAW96262 EAW96263 EAW96264 Q9BY84 AB051487 BAB21791 AB052156 BAB40814 AF506796 AAN75120 AK022103 AK055973 BAB71060 AK093617 AK098310 AL137633 AY038927 AAK69770 BC031643 AAH31643 BC042101 AAH42101 BC109234 AAI09235 BC109235 AAI09236 DB094627 XM_005253488 XP_005253545 XM_006719155 XP_006719218 XM_011520856 XP_011519158 XM_011520857 XP_011519159 XM_011548878 XP_011547180 XM_011548879 XP_011547181 XM_011548880 XP_011547182 XM_011548881 XP_011547183 NM_030640 NP_085143 |
Function | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}. |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles. |
Top Pathways | MAPK signaling pathway |
MKP-7 CRISPR/Cas9 KO Plasmid (h) - sc-405727 from Santa Cruz Biotechnology
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MKP-7 HDR Plasmid (h) - sc-405727-HDR from Santa Cruz Biotechnology
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MKP-7 Double Nickase Plasmid (h) - sc-405727-NIC from Santa Cruz Biotechnology
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MKP-7 Double Nickase Plasmid (h2) - sc-405727-NIC-2 from Santa Cruz Biotechnology
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MKP-7 CRISPR Activation Plasmid (h) - sc-405727-ACT from Santa Cruz Biotechnology
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MKP-7 CRISPR Activation Plasmid (h2) - sc-405727-ACT-2 from Santa Cruz Biotechnology
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MKP-7 Lentiviral Activation Particles (h) - sc-405727-LAC from Santa Cruz Biotechnology
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MKP-7 Lentiviral Activation Particles (h2) - sc-405727-LAC-2 from Santa Cruz Biotechnology
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MKP-7 siRNA (h) - sc-61052 from Santa Cruz Biotechnology
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MKP-7 shRNA Plasmid (h) - sc-61052-SH from Santa Cruz Biotechnology
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MKP-7 shRNA (h) Lentiviral Particles - sc-61052-V from Santa Cruz Biotechnology
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DUSP16 RNAi - H00080824-R01 from Novus Biologicals
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MISSION® esiRNA - EHU157361 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0110 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0109 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7548 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7548 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07290 from Sigma-Aldrich
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DUSP16 siRNA (Human) - CRJ2924 from Cohesion Biosciences
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DUSP16 - MBS8232150 from MyBioSource
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shRNA set against Human DUSP16 (NM_030640.2) - SHH281745 from Creative biogene
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Human DUSP16 siRNA - orb273425 from Biorbyt
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DUSP16 shRNA Plasmid (Human) - CHJ2924 from Cohesion Biosciences
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DUSP16 miRNA 3'UTR clone - MiUTR3H-09026 from Creative biogene
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