| Gene Symbol |
SLC20A2
|
| Entrez Gene |
6575
|
| Alt Symbol |
GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 20 (phosphate transporter), member 2
|
| Other Description |
gibbon ape leukemia virus receptor 2|murine leukemia virus, amphotropic, receptor for|sodium-dependent phosphate transporter 2
|
| Swissprots |
Q08357
|
| Accessions |
AGG19227 EAW63213 EAW63214 EAW63215 Q08357 AK291202 BAF83891 AK295952 BAG58733 AK314774 BAG37311 BC028600 AAH28600 DA418477 DQ891538 ABM82464 DQ894727 ABM85653 H10927 L20852 AAA18018 XM_005273613 XP_005273670 XM_005273615 XP_005273672 XM_006716390 XP_006716453 XM_006716391 XP_006716454 NM_001257180 NP_001244109 NM_001257181 NP_001244110 NM_006749 NP_006740
|
| Function |
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:8302848}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:9151850}; Multi-pass membrane protein {ECO:0000269|PubMed:9151850}.
|
| Tissue Specificity |
Ubiquitously expressed.
|