Recombinant Human R-Spondin 3

• Supplier: R&D Systems
• Catalog: 3500-RS-025
• Category: Protein
• Nature: Recombinant
• Source: Chinese Hamster Ovary cell line, CHO-derived, Gln22-His272
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• SwissProt/Accession: Q9BXY4
• Gene: RSPO3

Product References

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of - Interaction with both ZNRF3 and LGR4 is required for the signalling activity of

Xie Y, Zamponi R, Charlat O, Ramones M, Swalley S, Jiang X, Rivera D, Tschantz W, Lu B, Quinn L, Dimitri C, Parker J, Jeffery D, Wilcox SK, Watrobka M, LeMotte P, Granda B, Porter JA, Myer VE, Loew A, Cong F. EMBO Rep. 2013 Dec;14(12):1120-6.

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. - ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F. Nature. 2012 Apr 29;485(7397):195-200.

Widespread potential for growth-factor-driven resistance to anticancer kinase - Widespread potential for growth-factor-driven resistance to anticancer kinase

Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J. Nature. 2012 Jul 26;487(7408):505-9.