RSPO3

Gene Symbol	RSPO3
Entrez Gene	84870
Alt Symbol	CRISTIN1, PWTSR, THSD2
Species	Human
Gene Type	protein-coding
Description	R-spondin 3
Other Description	R-spondin 3 homolog|R-spondin-3|protein with TSP type-1 repeat|roof plate-specific spondin-3|thrombospondin type-1 domain-containing protein 2|thrombospondin, type I, domain containing 2
Swissprots	Q96K87 Q5VTV4 B2RC27 Q9BXY4
Accessions	EAW48114 EAW48115 EAW48116 Q9BXY4 AA568446 AF086298 AF251057 AAK34947 AI095468 AK314912 BAG37424 BC022367 AAH22367 DQ891407 ABM82333 DQ894583 ABM85509 NM_032784 NP_116173
Function	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.
Subcellular Location	Secreted {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. {ECO:0000269|PubMed:12463421}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RSPO3 protein fragment - ab174048 from Abcam Category Protein Prices $372.00 Sizes 50 µg Source HEK 293 cells Species Human

Human RSPO3 peptide - ab135941 from Abcam Category Peptide Species Human

Human RSPO3 protein fragment - ab192287 from Abcam Category Protein Source HEK 293 cells Species Human

RSPO3 Antibody Blocking Peptide - LS-E22198 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RSPO3 Antibody Blocking Peptide - LS-E27534 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

R-Spondin-3 recombinant protein - GTX53854 from GeneTex Category Protein Prices $199.00 Sizes 20 μg Source CHO cells

Recombinant Human R-Spondin 3 - 3500-RS-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln22-His272

Recombinant Human R-Spondin 3, CF - 3500-RS-025/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln22-His272

Human RSPO3 protein - orb180392 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293 Species Human

Human RSPO3 protein - orb191072 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

RSPO3 Peptide - AC21-2356-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RSPO3 - AR31197PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source CHO cells Species Human

RSPO3 - AR31197PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source CHO cells Species Human

RSPO3 - P6139 from Acris Antibodies Category Protein Prices $580.00 Sizes 20 µg Species Human

R-Spondin-3, Recombinant Human - 213-10378-1 from RayBiotech Category Protein Prices $75.00 Sizes 1 µg Source CHO cells Species Human

Recombinant Human R-Spondin-3 - 213-10378-2 from RayBiotech Category Protein Prices $190.00 Sizes 2 µg Source CHO cells Species Human

R-Spondin-3, Human, Recombinant - 28-10282 from ARP American Research Products Category Protein Prices $99.00, $102.00, $199.00 Sizes 5 µg, 1 mg, 20 µg Source CHO cells Species Human

RSPO3 Peptide - 8153P from ProSci Category Peptide Species Human

RSPO3 Peptide - 42-699P from ProSci Category Peptide Species Human

R Spondin 3 (22-146) Recombinant Protein - 96-661 from ProSci Category Protein Prices $375.00 Sizes 50 µg Source HEK293 cells Species Human

RSPO3 fusion protein - Ag9664 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RSPO3 fusion protein - ag9899 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RSPO3, His tagged - RSPO3-3883H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human RSPO3, GST-tagged - RSPO3-2455H from Creative Biomart Category Protein Source E.coli Species Human

Human R-Spondin3 Recombinant - RKQ9BXY4 from Reprokine Category Protein Prices $160.00, $480.00, $3,500.00 Sizes 10 µg, 50 µg, 500 µg Source Optimized DNA sequence encoding peptidase domain of Human R-Spondin3 (GLN22-VAL146) including a C-terminal His tag was expressed in HEK293 cells. Species Human

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