Murine IL-36RA protein

• Supplier: Biorbyt
• Catalog: orb107771
• Category: Protein
• Prices: $221.00, $357.00, $553.00, $910.00
• Sizes: 2 μg, 10 μg, 100 μg, 250 μg
• Applications: SDS-PAGE HPLC
• Species Reactivities: Mouse
• Nature: Recombinant
• Source: E.coli
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Gene: IL36RN
• Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGVQGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFLCTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
• Description: Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes.IL-36RA hasbeen reported to antagonize the biological activity of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9). Furthermore, itcould constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonistand interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirectevidence suggests it is IL-1Rrp2. Recombinant murine interleukin-36 RA contains 154 amino acid residues and it shares 91 %a.a. sequence identity with human IL-36RA.