IL36RN

Gene Symbol	IL36RN
Entrez Gene	26525
Alt Symbol	FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14
Species	Human
Gene Type	protein-coding
Description	interleukin 36 receptor antagonist
Other Description	IL-1 related protein 3|IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)|IL-1ra homolog 1|IL1F5 (Canonical product IL-1F5a)|interleukin 1 family, member 5 (delta)|interleukin-1 HY1|interleukin-1 receptor antagonist homolog 1|interleukin-1-like protein 1|interleukin-36 receptor antagonist protein
Swissprots	Q7RTZ6 Q56AT9 A8K2I4 Q9UBH0
Accessions	AAF76981 AAX59031 AAY14990 CAB67704 CAC27298 CAD29877 EAW73617 EAW73618 Q9UBH0 AF186094 AAF02757 AF201830 AAF25210 AF230377 AAF91274 AJ242737 CAB59822 AJ242738 CAB59823 AK002125 AK290249 BAF82938 AY359117 AAQ89475 BC000945 BC024747 AAH24747 DQ890702 ABM81628 DQ893886 ABM84812 NM_012275 NP_036407 NM_173170 NP_775262
Function	Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
Subcellular Location	Secreted.
Tissue Specificity	Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. {ECO:0000269|PubMed:11466363}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL36RN full length protein - ab176050 from Abcam Category Protein Prices $79.00 Sizes 25 µg Source E. coli Species Human

Cow IL36RN full length protein - ab87465 from Abcam Category Protein Prices $252.00 Sizes 25 µg Source Yeast Species Bovine

Human IL36RN full length protein - ab151905 from Abcam Category Protein Source E. coli Species Human

Human IL36RN full length protein - ab187485 from Abcam Category Protein Source E. coli Species Human

IL36RN / IL1F5 Antibody Blocking Peptide - LS-E1565 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL36RN / IL1F5 Antibody Blocking Peptide - LS-E20112 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL36RN / IL1F5 Antibody Blocking Peptide - LS-E20113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-36Ra/IL-1F5 Protein - NBP2-34872 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

IL1F5-Antibody-N-term-Blocking-peptide - BP12304a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IL-36Ra/IL-1F5 - 1275-IL-025 from R&D Systems Category Protein Source E. coli-derived, Val2-Asp155

Recombinant Human IL-36Ra/IL-1F5, CF - 1275-IL-025/CF from R&D Systems Category Protein Source E. coli-derived, Val2-Asp155

Human IL-36RA protein - orb107770 from Biorbyt Category Protein Prices $221.00, $357.00, $553.00, $910.00 Sizes 5 μg, 25 μg, 100 μg, 250 μg Source E.coli

Human IL1F5 protein (Native) - orb139144 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human CXCL10 protein (Native) - orb138655 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human IL36RN protein - orb168594 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E. coli

Mouse IL36RN protein - orb168607 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Mouse

Human IL1RA protein - orb49477 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Murine IL-36RA protein - orb107771 from Biorbyt Category Protein Prices $221.00, $357.00, $553.00, $910.00 Sizes 2 μg, 10 μg, 100 μg, 250 μg Source E.coli Species Mouse

Human IL36RN protein - orb244952 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

IL1F5 Blocking Peptide - 33R-4997 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IL36RN protein (His tag) - 80R-3954 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

Human Interleukin 1 Delta Protein - abx067396 from Abbexa Category Protein Source E.coli Species Human

IL1F5 / IL1L1 - AR31110PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source E. coli Species Human

IL1F5 / IL1L1 - AR31110PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source E. coli Species Human

IL1F5 / IL1L1 (1-155, His-tag) - AR51639PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

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