Recombinant Human Related RAS Viral (r-ras) Oncogene Homolog 2

• Supplier: Genway Biotech
• Catalog: GWB-1DD700
• Category: Protein
• Prices: $75.00, $165.00, $1,195.00
• Sizes: 10 μg, 50 μg, 1000 μg
• Species Reactivities: Human
• Nature: Recombinant
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• SwissProt/Accession: P62070
• Gene: RRAS2
• Sequence: MGSSHHHHHHSSGLVPRGSHM A A A GWRDGSGQ E KYRLVVVGGGGVGKS A LTIQFIQSYFVTDYDPTI E DSYTKQCVIDDR A A RLDILDT A GQ E E FG A MR E QYMRTG E GFLLVFSVTDRGSF E E IYKFQRQILRVKDRD E FPMILIGNK A DLDHQRQVTQ E E GQQL A RQLKVTYM E A S A KIRMNVDQ A FH E LVRVIRKFQ E Q E CPPSP E PTRK E KDKKGCHC. Introduction: RRAS2 (RAS viral (r-ras) oncogene homolog 2) is a member of the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. RRAS2 is a plasma membrane-associated GTP-binding protein with GTPase activity. RRAS2 is implicated in the pathogenesis of human cancers. Hence, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, as these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. RRAS2 might transduce growth inhibitory signals across the cell membrane, exerting its effect via an effector shared with the Ras proteins b
• Description: RRAS2 (RAS viral (r-ras) oncogene homolog 2) is a member of the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane