Recombinant Human LRP-6 Fc Chimera Protein, CF
| Name | Recombinant Human LRP-6 Fc Chimera Protein, CF |
|---|---|
| Supplier | R&D Systems |
| Catalog | 1505-LR |
| Category | Protein |
| Prices | $329.00 |
| Sizes | 25 µg |
| Species Reactivities | Human |
| Nature | Recombinant |
| Source | Mouse myeloma cell line, NS0-derived Human LRP-6 (Ala20 - Pro1368) Accession # O75581 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus |
| Purity | >80%, by SDS-PAGE under reducing conditions and visualized by silver stain |
| Bioactivity | Measured by its binding ability in a functional ELISA. rhLRP-6/Fc Chimera binds rhDkk-1, biotin with an apparent K D <25 nM. Biotinylated rmWnt-3a immobilized on a streptavidin-coated plate at 1 µg/mL can bind rhLRP-6/Fc Chimera with a linear range of 0.2-10 µg/mL. Optimal concentrations should be determined by each laboratory for each application. |
| Endotoxin | <0.1 EU per 1 μg of the protein by the LAL method. |
| SwissProt/Accession | O75581 |
| Gene | LRP6 |
| Sequence | Ala20 |
| Supplier Page | Shop |
Product images
When Recombinant Human B7-2/CD86 (9090-B2) is coated at 0.5 µg/mL, Recombinant Human CTLA-4 Fc Chimera (Catalog # 7268-CT) binds with a typical ED 50 of 7-42 ng/mL.
Product References
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Jackson H, Granger D, Jones G, Anderson L, Friel S, Rycroft D, Fieles W, Tunstead J, Steward M, Wattam T, Walker A, Griggs J, Al-Hajj M, Shelton C. Mol Cancer Res. 2016 Sep;14(9):859-68.
Thiazolidinediones increase the wingless-type MMTV integration site family (WNT) - Thiazolidinediones increase the wingless-type MMTV integration site family (WNT)
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Liu CC, Pearson C, Bu G. J Biol Chem. 2009 May 29;284(22):15299-307.
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes - Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes
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Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G. Nat Med. 2007 Feb;13(2):156-63. Epub 2007 Jan 21.