LRP6

Gene Symbol	LRP6
Entrez Gene	4040
Alt Symbol	ADCAD2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 6
Other Description	LRP-6|low-density lipoprotein receptor-related protein 6
Swissprots	O75581 Q17RZ2
Accessions	AAD21410 CCF76957 CDM49020 EAW96253 O75581 AA126261 AB209683 BAD92920 AF074264 AAC33006 AK074543 BAG51971 AK074902 BAG52027 AK094666 AK124760 BC029941 BC117136 AAI17137 BC126405 AAI26406 BC143725 AAI43726 BP229563 XM_006719078 XP_006719141 XM_011520671 XP_011518973 XM_011548873 XP_011547175 XM_011548874 XP_011547176 XR_429034 XR_429035 XR_953254 XR_953255 NM_002336 NP_002327
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). {ECO:0000250}.
Tissue Specificity	Widely coexpressed with LRP5 during embryogenesis and in adult tissues.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LRP5 + LRP6 peptide - ab51923 from Abcam Category Peptide

LRP6 (phospho S1490) peptide - ab192756 from Abcam Category Peptide

LRP6 Antibody Blocking Peptide - LS-E25789 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRP6 Antibody Blocking Peptide - LS-E8099 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRP6-Antibody-C-term-T1546-Blocking-Peptide - BP6158a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRP6 blocking peptide - GTX89658-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human LRP-6 Fc Chimera, CF - 1505-LR-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human LRP6 Protein - abx067823 from Abbexa Category Protein Source E.coli Species Human

LRP6 Peptide - AC21-0619-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Low Density Lipoprotein Receptor Related Protein - 20-8682 from ARP American Research Products Category Protein Prices $507.00 Sizes 50 µg Source E.coli Species Human

LRP6 Peptide - 45-847P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

LRP6 fusion protein - Ag24264 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET28a Species Human

Recombinant Human LRP6, Fc Chimera - LRP6-1040H from Creative Biomart Category Protein Source NSO Cells Species Human

Recombinant Low Density Lipoprotein Receptor Related Protein 6 (LRP6) - RPD105Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Low-density lipoprotein receptor-related protein 6(LRP6) ,partial - CSB-YP013102HU CSB-EP013102HU CSB-BP013102HU CSB-MP013102HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human LRP-6 Fc Chimera Protein, CF - 1505-LR from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source Mouse myeloma cell line, NS0-derived Human LRP-6 (Ala20 - Pro1368) Accession # O75581 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus Species Human

LRP6, Peptide - MBS425279 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

LRP-6 Recombinant Protein Antigen - NBP1-86345PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LRP6-Antibody-Center-Blocking-Peptide - BP6158d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRP6-Antibody-N-term-Blocking-Peptide - BP6158c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRP6-Antibody-C-term-H1497-Blocking-Peptide - BP6158b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRP6 Peptide, Human - M34GP08863H from Creative Peptides Category Peptide Source Synthetic. Species Human

LRP6 Recombinant Protein (OPCD05031) - OPCD05031 from Aviva Systems Biology Category Protein Source E.coli Species Human

Low Density Lipoprotein Receptor Related Protein 6 (LRP6), Recombinant Protein - MBS2010787 from MyBioSource Category Protein Prices $185.00, $395.00, $605.00 Sizes 10 µg, 50 µg, 100 µg Source E. coli Species Human

Low-density lipoprotein receptor-related protein 6 (LRP6), partial, Recombinant Protein - MBS1116313 from MyBioSource Category Protein Prices $975.00, $975.00, $1,200.00, $1,200.00, $1,445.00, $1,445.00, $1,900.00, $1,900.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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