Recombinant Human IL-15 R alpha Fc Chimera Protein, CF

• Supplier: R&D Systems
• Catalog: 147-IR
• Category: Protein
• Prices: $329.00
• Sizes: 100 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: Spodoptera frugiperda , Sf 21 (baculovirus)-derived Human IL-15 R alpha (Ile31-Thr172) Accession # EAW86418 IEGRDMD Human IgG 1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Bioactivity: Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. Ruchatz, H. et al . (1998) J. Immunol. 160 :5654. The ED 50 for this effect is 0.005‑0.015 µg/mL.
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: EAW86418
• Gene: IL15RA
• Sequence: Ile31

Product References

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to - A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to

Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD. PLoS Pathog. 2016 Apr 15;12(4):e1005545.

IL-15 expression on RA synovial fibroblasts promotes B cell survival. - IL-15 expression on RA synovial fibroblasts promotes B cell survival.

Benito-Miguel M, Garcia-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibanez T, Bonilla-Hernan MG, Perez de Ayala C, Sanchez-Mateos P, Martin-Mola E, Miranda-Carus ME. PLoS One. 2012;7(7):e40620.

Human T cells constitutively express IL-15 that promotes ex vivo T cell - Human T cells constitutively express IL-15 that promotes ex vivo T cell

Miranda-Carus ME, Benito-Miguel M, Llamas MA, Balsa A, Martin-Mola E. J Immunol. 2005 Sep 15;175(6):3656-62.

IL-15 and the initiation of cell contact-dependent synovial fibroblast-T - IL-15 and the initiation of cell contact-dependent synovial fibroblast-T

Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E. J Immunol. 2004 Jul 15;173(2):1463-76.