IL15RA

Gene Symbol	IL15RA
Entrez Gene	3601
Alt Symbol	CD215
Species	Human
Gene Type	protein-coding
Description	interleukin 15 receptor, alpha
Other Description	interleukin 15 receptor alpha isoform EM2|interleukin 15 receptor alpha isoform IC2|interleukin 15 receptor alpha isoform IC3|interleukin 15 receptor alpha isoform IC4|interleukin 15 receptor alpha isoform IC5|interleukin 15 receptor alpha isoform IC6|interleukin 15 receptor alpha isoform IC7|interleukin 15 receptor alpha isoform IC8|interleukin-15 receptor subunit alpha
Swissprots	Q6B0J2 Q13261 Q7LDR4 Q3B769 Q5JVA2 Q5JVA4 B4E2C2 Q7Z609 Q5JVA1
Accessions	AAP69528 CCA64145 CCA64146 EAW86415 EAW86416 EAW86417 EAW86418 EAW86419 EAW86420 EAW86421 EAW86422 Q13261 AA847313 AF035279 AAB88175 AK304211 BAG65084 BC065506 AAH65506 BC074726 AAH74726 BC107777 AAI07778 BC121140 AAI21141 BC121141 AAI21142 BM546106 CR457064 CAG33345 CR542023 CAG46820 DC298692 HQ401283 AEP26933 JX987304 AFY11387 JX987305 AFY11388 JX987306 AFY11389 JX987307 AFY11390 JX987308 AFY11391 JX987309 AFY11392 JX987310 AFY11393 JX987311 AFY11394 U31628 AAC50312 XM_011519461 XP_011517763 XM_011519462 XP_011517764 XM_011519463 XP_011517765 XM_011519464 XP_011517766 XM_011519465 XP_011517767 XM_011519466 XP_011517768 XM_011519467 XP_011517769 XM_011519468 XP_011517770 XM_011519469 XP_011517771 XM_011519470 XP_011517772 XM_011519471 XP_011517773 XM_011519472 XP_011517774 XM_011519473 XP_011517775 XM_011519474 XP_011517776 XM_011519475 XP_011517777 XM_011519476 XP_011517778 XM_011519477 XP_011517779 NM_001243539 NP_001230468 NM_001256765 NP_001243694 NM_002189 NP_002180 NM_172200 NP_751950 NR_046362
Function	High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. {ECO:0000269|PubMed:11714793, ECO:0000269|PubMed:8530383}.
Subcellular Location	Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Tissue Specificity	Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. {ECO:0000269|PubMed:10480910, ECO:0000269|PubMed:12114302, ECO:0000269|PubMed:8530383}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Intestinal immune network for IgA production, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL15RA protein fragment - ab114831 from Abcam Category Protein Source Wheat germ Species Human

IL15RA Antibody Blocking Peptide - LS-E6182 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL15RA Antibody Blocking Peptide - LS-E31400 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IL15RA Antibody Blocking Peptide - LS-E23157 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-15 R alpha Protein - H00003601-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IL15RA-Antibody-Center-Blocking-Peptide - BP18818c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IL-15 R alpha Fc Chimera, CF - 147-IR-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Human IL-15 R alpha Fc Chimera (HEK293), CF - 7194-IR-050 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived

IL15RA - H00003601-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IL15RA - H00003601-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IL-15RA Peptide - 7233P from ProSci Category Peptide Species Human

IL15RA fusion protein - Ag10200 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

IL15RA fusion protein - ag10151 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human IL15RA - IL15RA-28598TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Interleukin 15 Receptor, Alpha, Fc-His - IL15RA-1653H from Creative Biomart Category Protein Source Sf 21 Insect Cells.

Recombinant Human IL15RA, His-tagged - IL15RA-14151H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human IL15RA - IL15RA-1655H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human IL15RA, Fc Chimera - IL15RA-530H from Creative Biomart Category Protein Source Baculovirus Sf 21 Insect cells Species Human

IL-15Rα (P129) Peptide - BS3969P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Interleukin-15 receptor subunit alpha(IL15RA) - CSB-YP614402HU CSB-EP614402HU CSB-BP614402HU CSB-MP614402HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human IL-15 R alpha Fc Chimera Protein, CF - 147-IR from R&D Systems Category Protein Prices $329.00 Sizes 100 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Human IL-15 R alpha (Ile31-Thr172) Accession # EAW86418 IEGRDMD Human IgG 1 (Pro100-Lys330) 6-His tag N-terminus C-terminus Species Human

Recombinant Human IL-15 R alpha Fc Chimera (HEK293), CF - 7194-IR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Human embryonic kidney cell, HEK293-derived Human IL-15 R alpha (Met1 - Thr205) Accession # Q13261 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus Species Human

IL15RA Peptide - abx164618 from Abbexa Category Peptide Species Human

Human IL-15 Receptor Subunit alpha protein - orb334282 from Biorbyt Category Protein Prices $204.00, $366.00, $1,496.00, $2,108.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

IL15RA Peptide, Human - M34GP07541H from Creative Peptides Category Peptide Source Synthetic. Species Human

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