Recombinant Human Semaphorin 3E Protein, CF

• Supplier: R&D Systems
• Catalog: 3239-S3
• Category: Protein
• Prices: $329.00
• Sizes: 25 µg
• Species Reactivities: Human
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived Thr25-Ser775 (Arg557Ala and Arg560Ala), with an N-terminal 10-His tag
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Bioactivity: Measured by its ability to inhibit the proliferation of HUVEC human umbilical vein endothelial cells. Moriya, J. et al . (2010) Circ. Res. 106 :391. The ED 50 for this effect is typically 0.3-1.5 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human Plexin D1 (Catalog # 4160-PD ) is coated at 5 μg/mL, Recombinant Human Semaphorin 3E binds with an apparent K D <2 nM.
• Endotoxin: <0.10 EU per 1 μg of the protein by the LAL method.
• SwissProt/Accession: O15041
• Gene: SEMA3E
• Sequence: His

Product References

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in - Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in

Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A. J Clin Invest. 2011 May;121(5):1974-85.

Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation - Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation

Kusuhara S, Fukushima Y, Fukuhara S, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, Uemura A. PLoS One. 2012;7(9):e45858.

Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial - Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial

Meda C, Molla F, De Pizzol M, Regano D, Maione F, Capano S, Locati M, Mantovani A, Latini R, Bussolino F, Giraudo E. J Immunol. 2012 Apr 15;188(8):4081-92.