| Gene Symbol |
GALP
|
| Entrez Gene |
85569
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
galanin-like peptide
|
| Other Description |
alarin|gal-like peptide
|
| Swissprots |
Q9UBC7 A1KXL3
|
| Accessions |
EAW72431 Q9UBC7 AF188492 AAF19724 AF188493 AAF19725 AY329637 AAQ99038 BC141468 AAI41469 BC148722 AAI48723 NM_001145546 NP_001139018 NM_033106 NP_149097
|
| Function |
Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.
|