| Gene Symbol |
PRIMPOL
|
| Entrez Gene |
201973
|
| Alt Symbol |
CCDC111, MYP22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
primase and polymerase (DNA-directed)
|
| Other Description |
DNA-directed primase/polymerase protein|coiled-coil domain containing 111|coiled-coil domain-containing protein 111|hPrimpol1
|
| Swissprots |
Q5HYJ9 D6RDM1 Q96LW4 D3DP55
|
| Accessions |
CCQ43865 EAX04667 EAX04668 EAX04669 EAX04670 EAX04671 EAX04672 Q96LW4 AK057729 BAB71553 AK307317 BC018930 BC047467 BC064600 AAH64600 BP245596 BX647575 CAI46079 XM_011531719 XP_011530021 XM_011531720 XP_011530022 XM_011531721 XP_011530023 XM_011531722 XP_011530024 XM_011531723 XP_011530025 XM_011531724 XP_011530026 XM_011531725 XP_011530027 XM_011531726 XP_011530028 XM_011531727 XP_011530029 XM_011531728 XP_011530030 XM_011531729 XP_011530031 XM_011531730 XP_011530032 XM_011531731 XP_011530033 XM_011531732 XP_011530034 XR_938701 XR_938702 NM_001300767 NP_001287696 NM_001300768 NP_001287697 NM_152683 NP_689896
|
| Function |
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH. {ECO:0000269|PubMed:24126761, ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:24240614, ECO:0000269|PubMed:24267451}.
|
| Subcellular Location |
Nucleus. Mitochondrion matrix. Note=Present in the nucleus, but a larger fraction is localized inside mitochondria. Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles.
|