PRIMPOL

Gene Symbol PRIMPOL
Entrez Gene 201973
Alt Symbol CCDC111, MYP22
Species Human
Gene Type protein-coding
Description primase and polymerase (DNA-directed)
Other Description DNA-directed primase/polymerase protein|coiled-coil domain containing 111|coiled-coil domain-containing protein 111|hPrimpol1
Swissprots Q5HYJ9 D6RDM1 Q96LW4 D3DP55
Accessions CCQ43865 EAX04667 EAX04668 EAX04669 EAX04670 EAX04671 EAX04672 Q96LW4 AK057729 BAB71553 AK307317 BC018930 BC047467 BC064600 AAH64600 BP245596 BX647575 CAI46079 XM_011531719 XP_011530021 XM_011531720 XP_011530022 XM_011531721 XP_011530023 XM_011531722 XP_011530024 XM_011531723 XP_011530025 XM_011531724 XP_011530026 XM_011531725 XP_011530027 XM_011531726 XP_011530028 XM_011531727 XP_011530029 XM_011531728 XP_011530030 XM_011531729 XP_011530031 XM_011531730 XP_011530032 XM_011531731 XP_011530033 XM_011531732 XP_011530034 XR_938701 XR_938702 NM_001300767 NP_001287696 NM_001300768 NP_001287697 NM_152683 NP_689896
Function DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH. {ECO:0000269|PubMed:24126761, ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:24240614, ECO:0000269|PubMed:24267451}.
Subcellular Location Nucleus. Mitochondrion matrix. Note=Present in the nucleus, but a larger fraction is localized inside mitochondria. Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles.

CCDC111 CRISPR/Cas9 KO Plasmid (h) - sc-404310 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 HDR Plasmid (h) - sc-404310-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 Double Nickase Plasmid (h) - sc-404310-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 Double Nickase Plasmid (h2) - sc-404310-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 CRISPR Activation Plasmid (h) - sc-404310-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 CRISPR Activation Plasmid (h2) - sc-404310-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 Lentiviral Activation Particles (h) - sc-404310-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 Lentiviral Activation Particles (h2) - sc-404310-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CCDC111 siRNA (h) - sc-89324 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC111 shRNA Plasmid (h) - sc-89324-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CCDC111 shRNA (h) Lentiviral Particles - sc-89324-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU105571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5457 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5457 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01727 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01727

PRIMPOL siRNA (Human) - CRJ6310 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CCDC111 (NM_152683.2) - SHH255837 from Creative biogene

Category siRNA
Species Reactivities Human

Human PRIMPOL siRNA - orb276811 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PRIMPOL shRNA Plasmid (Human) - CHJ6310 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCDC111 miRNA 3'UTR clone - MiUTR3H-14304 from Creative biogene

Species Reactivities Human
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