| Gene Symbol |
RGCC
|
| Entrez Gene |
28984
|
| Alt Symbol |
C13orf15, RGC-32, RGC32, bA157L14.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of cell cycle
|
| Other Description |
regulator of cell cycle RGCC|response gene to complement 32 protein
|
| Swissprots |
Q6NZ48 Q9UL69 Q9H4X1
|
| Accessions |
EAX08663 EAX08664 Q9H4X1 AF036549 AAF04336 AK091099 AK095079 BC038706 BC066334 AAH66334 BU679672 DB451897 XM_011535051 XP_011533353 XR_941564 XR_941565 NM_014059 NP_054778
|
| Function |
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.
|
| Tissue Specificity |
Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:15713436}.
|