| Gene Symbol | MPST |
|---|---|
| Entrez Gene | 4357 |
| Alt Symbol | MST, TST2, TUM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mercaptopyruvate sulfurtransferase |
| Other Description | 3-mercaptopyruvate sulfurtransferase|human liver rhodanese|tRNA thiouridin modification protein 1 |
| Swissprots | O75750 B3KP52 P25325 J3KPV7 Q6FHN9 A8MZ34 |
| Accessions | ABB16334 ABB16335 ABB16336 EAW60133 EAW60134 EAW60135 P25325 AB208824 BAD92061 AK055733 BAG51564 AW778940 BC003508 AAH03508 BC009450 BC016737 AAH16737 BC018717 AAH18717 BI463699 BI597227 BQ072744 BT019636 AAV38442 BX406051 CR456523 CAG30409 CR541712 CAG46513 CU013123 CAK54554 CU013411 CAK54853 CX866643 CX872464 DB450861 X59434 CAA42060 XM_005261610 XP_005261667 XM_011530195 XP_011528497 XM_011530196 XP_011528498 NM_001013436 NP_001013454 NM_001130517 NP_001123989 NM_021126 NP_066949 NM_001013440 NR_024038 |
| Function | Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. |
| Top Pathways | Sulfur metabolism, Cysteine and methionine metabolism, Sulfur relay system |