CCND3

Gene Symbol	CCND3
Entrez Gene	896
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cyclin D3
Other Description	D3-type cyclin|G1/S-specific cyclin-D3
Swissprots	E9PB36 Q96F49 B2RD63 Q6FG62 B3KQ22 E9PAS4 Q5T8J0 P30281
Accessions	AAA51929 AAM51826 EAX04070 EAX04071 EAX04072 EAX04073 EAX04074 EAX04075 EAX04076 P30281 AB209825 BAD93062 AK055519 BAG51531 AK057206 BAG51884 AK096276 BAG53245 AK097856 AK299187 BAG61231 AK303452 BAG64497 AK315421 BAG37810 BC011616 AAH11616 BE247367 BG996045 BX117734 CA424172 CR542246 CAG47042 DA069566 DA411470 DA999482 DB001987 DB104254 DB110132 DB544217 DC360231 DC405843 DQ891748 ABM82674 DQ895130 ABM86056 DR761231 M90814 AAA51927 M92287 AAA52137 XM_011514971 XP_011513273 XM_011514972 XP_011513274 NM_001136017 NP_001129489 NM_001136125 NP_001129597 NM_001136126 NP_001129598 NM_001287427 NP_001274356 NM_001287434 NP_001274363 NM_001760 NP_001751
Function	Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}. Membrane {ECO:0000269|PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	HTLV-I infection, Hippo signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDK4 + CCND3 full length protein - ab85646 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human CDK6 + CCND3 full length protein - ab84557 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human CDK6 + CCND3 full length protein - ab89010 from Abcam Category Protein Prices $297.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human CDK6 + CCND3 full length protein - ab80218 from Abcam Category Protein Prices $379.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Cyclin D3 full length protein - ab158041 from Abcam Category Protein Source Wheat germ Species Human

Human Cyclin D3 protein fragment - ab158042 from Abcam Category Protein Source Wheat germ Species Human

CCND3 / Cyclin D3 Antibody Blocking Peptide - LS-E10538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cyclin D3 Protein - H00000896-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cyclin D3 Protein - H00000896-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CCND3 Blocking Peptide - 33R-1779 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cyclin D3 - H00000896-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cyclin D3 - H00000896-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cyclin D3 - H00000896-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cyclin D3 - H00000896-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cyclin D3 fusion protein - Ag1292 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Cyclin D3 fusion protein - Ag22825 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

Recombinant Human CCND3 protein, GST-tagged - CCND3-839H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human CCND3 protein, His/T7-tagged - CCND3-840H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Human CDK6, His-tagged - CCND3-30307TH from Creative Biomart Category Protein

Recombinant Human Human CDK4 - CCND3-31094TH from Creative Biomart Category Protein

Recombinant Human Human CDK6, His-tagged - CCND3-31765TH from Creative Biomart Category Protein

Recombinant Human Human CDK6, His-tagged - CCND3-31771TH from Creative Biomart Category Protein

Recombinant Cyclin D3 (CCND3) - RPA587Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Cyclin D3 (G277) Peptide - AP0379P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Cyclin D3 (G277) Peptide - BS1393P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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