CCND3

Gene Symbol	CCND3
Entrez Gene	896
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cyclin D3
Other Description	D3-type cyclin|G1/S-specific cyclin-D3
Swissprots	E9PB36 Q96F49 B2RD63 Q6FG62 B3KQ22 E9PAS4 Q5T8J0 P30281
Accessions	AAA51929 AAM51826 EAX04070 EAX04071 EAX04072 EAX04073 EAX04074 EAX04075 EAX04076 P30281 AB209825 BAD93062 AK055519 BAG51531 AK057206 BAG51884 AK096276 BAG53245 AK097856 AK299187 BAG61231 AK303452 BAG64497 AK315421 BAG37810 BC011616 AAH11616 BE247367 BG996045 BX117734 CA424172 CR542246 CAG47042 DA069566 DA411470 DA999482 DB001987 DB104254 DB110132 DB544217 DC360231 DC405843 DQ891748 ABM82674 DQ895130 ABM86056 DR761231 M90814 AAA51927 M92287 AAA52137 XM_011514971 XP_011513273 XM_011514972 XP_011513274 NM_001136017 NP_001129489 NM_001136125 NP_001129597 NM_001136126 NP_001129598 NM_001287427 NP_001274356 NM_001287434 NP_001274363 NM_001760 NP_001751
Function	Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}. Membrane {ECO:0000269|PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	HTLV-I infection, Hippo signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cyclin D3 (DCS22) Mouse mAb - 2936 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (4 western blots), 100 µl (20 western blots) Host Mouse Clonality Monoclonal Clone DCS22

cyclin D3 (C-16) - sc-182 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

cyclin D3 (D-7) - sc-6283 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

cyclin D3 (18B6-10) - sc-453 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rat Clonality Monoclonal

cyclin D3 (H-292) - sc-755 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

cyclin D3 (DCS-22) - sc-56307 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

cyclin D3 (DCS-28) - sc-56308 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

cyclin D3 (1) - sc-135875 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-Cyclin D3 (phospho T283) antibody - ab55322 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Cyclin D3 (phospho T283) antibody - ab182639 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Cyclin D3 (phospho T283) antibody - ab195999 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Cyclin D3 antibody - ab63535 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Cyclin D3 antibody [DCS-22] - ab150755 from Abcam Prices $379.00 Sizes 250 µl Host Mouse Clonality Monoclonal Clone DCS-22

Anti-Cyclin D3 antibody [DCS-28.1] (Biotin) - ab79088 from Abcam Prices $376.00 Sizes 250 µl Host Mouse Clonality Monoclonal Clone DCS-28.1

Anti-Cyclin D3 antibody [EP463E] - ab52598 from Abcam Prices $397.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP463E

Anti-Cyclin D3 antibody [SPM241], prediluted - ab54238 from Abcam Prices $376.00 Sizes 7 ml Host Mouse Clonality Monoclonal Clone SPM241

Anti-CCND3 / Cyclin D3 Antibody - LS-C22536 from LifeSpan Bioscience Prices $605.00 Sizes 500 µl Host Mouse Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody - LS-C22537 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody (aa241-260) - LS-C22540 from LifeSpan Bioscience Prices $405.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody (Azide-free) - LS-C22545 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody - LS-C64103 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-22) - LS-C84868 from LifeSpan Bioscience Prices $650.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone DCS-22

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-22, Azide-free) - LS-C87948 from LifeSpan Bioscience Prices $590.00, $880.00 Sizes 100 µg, 200 µg Host Mouse Clonality Monoclonal Clone DCS-22

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-28.1, Biotin) - LS-C87950 from LifeSpan Bioscience Prices $325.00, $705.00, $1,050.00 Sizes 20 µg, 500 µl, 200 µg Host Mouse Clonality Monoclonal Clone DCS-28.1

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-28.1) - LS-C87949 from LifeSpan Bioscience Prices $280.00, $530.00, $810.00 Sizes 20 µg, 500 µl, 200 µg Host Mouse Clonality Monoclonal Clone DCS-28.1

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