PNN
| Gene Symbol | PNN |
|---|---|
| Entrez Gene | 5411 |
| Alt Symbol | DRS, DRSP, SDK3, memA |
| Species | Human |
| Gene Type | protein-coding |
| Description | pinin, desmosome associated protein |
| Other Description | 140 kDa nuclear and cell adhesion-related phosphoprotein|SR-like protein|desmosome-associated protein|domain-rich serine protein|melanoma metastasis clone A protein|neutrophil protein|nuclear protein SDK3|pinin |
| Swissprots | Q9UQR9 Q7KYL1 Q99738 Q9H307 B4DZX8 Q6P5X4 Q53EM7 O60899 Q9UHZ9 |
| Accessions | AAG33941 CBJ05784 CBJ21236 EAW65820 Q9H307 AK223612 BAD97332 AK292579 BAF85268 AK300164 BAG61946 AK303136 BAG64240 AK304622 BAG65404 BC062602 AAH62602 BG057344 BM850066 BQ938918 CD687183 U59479 AAB03391 U77718 AAB48304 Y09703 CAA70874 NM_002687 NP_002678 |
| Function | Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell- |
| Subcellular Location | Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein. |
| Tissue Specificity | Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. {ECO:0000269|PubMed:10095061, ECO:0000269|PubMed:8922384, ECO:0000269|PubMed:9447706}. |
| Top Pathways | RNA transport, mRNA surveillance pathway |
Pinin CRISPR/Cas9 KO Plasmid (h) - sc-405373 from Santa Cruz Biotechnology
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Pinin HDR Plasmid (h) - sc-405373-HDR from Santa Cruz Biotechnology
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Pinin Double Nickase Plasmid (h) - sc-405373-NIC from Santa Cruz Biotechnology
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Pinin Double Nickase Plasmid (h2) - sc-405373-NIC-2 from Santa Cruz Biotechnology
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Pinin CRISPR Activation Plasmid (h) - sc-405373-ACT from Santa Cruz Biotechnology
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Pinin CRISPR Activation Plasmid (h2) - sc-405373-ACT-2 from Santa Cruz Biotechnology
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Pinin Lentiviral Activation Particles (h) - sc-405373-LAC from Santa Cruz Biotechnology
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Pinin Lentiviral Activation Particles (h2) - sc-405373-LAC-2 from Santa Cruz Biotechnology
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Pinin siRNA (h) - sc-76142 from Santa Cruz Biotechnology
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Pinin shRNA Plasmid (h) - sc-76142-SH from Santa Cruz Biotechnology
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Pinin shRNA (h) Lentiviral Particles - sc-76142-V from Santa Cruz Biotechnology
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Pinin RNAi - H00005411-R01 from Novus Biologicals
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MISSION® esiRNA - EHU031411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17058 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17058 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09412 from Sigma-Aldrich
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PNN siRNA (Human) - CRH3620 from Cohesion Biosciences
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shRNA set against Human PNN (NM_002687.3) - SHH378724 from Creative biogene
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shRNA set against Human PNN(NM_002687.3) - SHR125124 from Creative biogene
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Pinin CRISPR/Cas9 KO Plasmid (h2) - sc-405373-KO-2 from Santa Cruz Biotechnology
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Pinin HDR Plasmid (h2) - sc-405373-HDR-2 from Santa Cruz Biotechnology
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Human PNN siRNA - orb264122 from Biorbyt
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PNN shRNA Plasmid (Human) - CHH3620 from Cohesion Biosciences
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PNN miRNA 3'UTR clone - MiUTR1H-08048 from Creative biogene
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