PNN

Gene Symbol	PNN
Entrez Gene	5411
Alt Symbol	DRS, DRSP, SDK3, memA
Species	Human
Gene Type	protein-coding
Description	pinin, desmosome associated protein
Other Description	140 kDa nuclear and cell adhesion-related phosphoprotein|SR-like protein|desmosome-associated protein|domain-rich serine protein|melanoma metastasis clone A protein|neutrophil protein|nuclear protein SDK3|pinin
Swissprots	Q9UQR9 Q7KYL1 Q99738 Q9H307 B4DZX8 Q6P5X4 Q53EM7 O60899 Q9UHZ9
Accessions	AAG33941 CBJ05784 CBJ21236 EAW65820 Q9H307 AK223612 BAD97332 AK292579 BAF85268 AK300164 BAG61946 AK303136 BAG64240 AK304622 BAG65404 BC062602 AAH62602 BG057344 BM850066 BQ938918 CD687183 U59479 AAB03391 U77718 AAB48304 Y09703 CAA70874 NM_002687 NP_002678
Function	Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-
Subcellular Location	Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
Tissue Specificity	Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. {ECO:0000269|PubMed:10095061, ECO:0000269|PubMed:8922384, ECO:0000269|PubMed:9447706}.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Pinin (T-15) - sc-74833 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Pinin (4FQ) - sc-101127 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Pinin antibody - ab108485 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Pinin antibody - ab57289 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-PNN / Pinin Antibody - LS-C91917 from LifeSpan Bioscience Prices $545.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239, AP) - LS-C266650 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239, Biotin) - LS-C266651 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (N-Terminus) - LS-C111911 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa193-242) - LS-C200504 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239, APC) - LS-C266652 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa647-696) - LS-C111912 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239, FITC) - LS-C266653 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa211-260) - LS-C120221 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239, Azide-free, HRP) - LS-C266654 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239, PE) - LS-C266655 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa216-248) - LS-C324138 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa201-301, Azide-free) - LS-C328251 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-PNN / Pinin Antibody (aa80-129) - LS-C170361 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (clone 2B4) - LS-C197938 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2B4

Anti-PNN / Pinin Antibody - LS-C334390 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (aa209-239) - LS-C163822 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PNN / Pinin Antibody (C-Terminus) - LS-C287853 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Pinin Antibody - NBP1-87784 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Pinin Antibody - NBP1-59136 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Pinin Antibody - NBP1-59133 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

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