| Gene Symbol |
KLHL42
|
| Entrez Gene |
57542
|
| Alt Symbol |
Ctb9, KLHDC5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 42
|
| Other Description |
cullin-3-binding protein 9|kelch domain containing 5|kelch domain-containing protein 5|kelch-like family, member 42|kelch-like protein 42
|
| Swissprots |
Q9P2K6 Q8N334 Q2VPK1
|
| Accessions |
EAW96570 EAW96571 Q9P2K6 AA687307 AB037761 BAA92578 AK002197 AK095405 BAG53048 AL118635 AL702640 BC028742 AAH28742 BC108669 AAI08670 BC137116 AAI37117 BC137117 AAI37118 BQ218827 BX497104 CA771366 CD521625 EU446834 ABZ92363 T83155 XM_011520791 XP_011519093 XR_931314 XR_931315 NM_020782 NP_065833
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. {ECO:0000269|PubMed:19261606}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19261606}. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.
|