Gene Symbol | CXCL2 |
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Entrez Gene | 2920 |
Alt Symbol | CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2, MIP2A, SCYB2 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-X-C motif) ligand 2 |
Other Description | C-X-C motif chemokine 2|GRO2 oncogene|MGSA beta|MIP2-alpha|gro-beta|growth-regulated protein beta|macrophage inflammatory protein 2-alpha|melanoma growth stimulatory activity beta |
Swissprots | P19875 Q6FGD6 Q9UPB8 |
Accessions | AAA03453 AAP13104 EAX05700 EAX05701 P19875 AF043340 AAC03540 AK308504 BC015753 AAH15753 BC053653 BX334969 CR542171 CAG46968 M36820 AAA63183 M57731 AAA63182 X53799 CAA37808 NM_002089 NP_002080 |
Function | Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. {ECO:0000269|PubMed:10725737}. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Chemokine signaling pathway, Salmonella infection, Legionellosis |
GROβ siRNA (h) - sc-43934 from Santa Cruz Biotechnology
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GROβ shRNA Plasmid (h) - sc-43934-SH from Santa Cruz Biotechnology
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GROβ shRNA (h) Lentiviral Particles - sc-43934-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6804 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6804 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05856 from Sigma-Aldrich
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CXCL2 siRNA (Human) - CRH1973 from Cohesion Biosciences
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CXCL2 - MBS829129 from MyBioSource
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shRNA set against Human CXCL2 (NM_002089.3) - SHH272201 from Creative biogene
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shRNA set against Human CXCL2(NM_002089.3) - SHG212921 from Creative biogene
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Human CXCL2 siRNA - orb262475 from Biorbyt
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CXCL2 shRNA Plasmid (Human) - CHH1973 from Cohesion Biosciences
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CXCL2 miRNA 3'UTR clone - MiUTR1H-02573 from Creative biogene
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