Gene Symbol | TCEA2 |
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Entrez Gene | 6919 |
Alt Symbol | TFIIS |
Species | Human |
Gene Type | protein-coding |
Description | transcription elongation factor A (SII), 2 |
Other Description | testis-specific S-II|transcription elongation factor A protein 2|transcription elongation factor S-II protein 2|transcription elongation factor TFIIS.1|transcription elongation factor TFIIS.l |
Swissprots | Q8TD38 B3KNM1 Q15560 Q8TD37 |
Accessions | AAC39553 EAW75168 EAW75169 EAW75170 Q15560 AJ844626 AJ844627 CAH59746 AK027824 BAG51383 AK226140 AW474513 BC014211 BC018896 AAH18896 BC031877 BC050623 AAH50623 BC050624 BC056407 BC098585 BI668232 BI756937 CB961240 CR456940 CAG33221 D50495 BAA09089 EU446904 ABZ92433 HG511555 XM_005260229 XP_005260286 XM_011529022 XP_011527324 XM_011529023 XP_011527325 XM_011529024 XP_011527326 XM_011529025 XP_011527327 XM_011529026 XP_011527328 XM_011529027 XP_011527329 NM_003195 NP_003186 NM_198723 NP_942016 |
Function | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. {ECO:0000269|PubMed:12034815}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Testis and ovary specific. {ECO:0000269|PubMed:8566795}. |
TCEA2 CRISPR/Cas9 KO Plasmid (h) - sc-411031 from Santa Cruz Biotechnology
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TCEA2 HDR Plasmid (h) - sc-411031-HDR from Santa Cruz Biotechnology
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TCEA2 Double Nickase Plasmid (h) - sc-411031-NIC from Santa Cruz Biotechnology
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TCEA2 Double Nickase Plasmid (h2) - sc-411031-NIC-2 from Santa Cruz Biotechnology
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TCEA2 CRISPR Activation Plasmid (h) - sc-411031-ACT from Santa Cruz Biotechnology
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TCEA2 CRISPR Activation Plasmid (h2) - sc-411031-ACT-2 from Santa Cruz Biotechnology
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TCEA2 Lentiviral Activation Particles (h) - sc-411031-LAC from Santa Cruz Biotechnology
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TCEA2 Lentiviral Activation Particles (h2) - sc-411031-LAC-2 from Santa Cruz Biotechnology
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TCEA2 siRNA (h) - sc-106605 from Santa Cruz Biotechnology
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TCEA2 shRNA Plasmid (h) - sc-106605-SH from Santa Cruz Biotechnology
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TCEA2 shRNA (h) Lentiviral Particles - sc-106605-V from Santa Cruz Biotechnology
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TFIIS RNAi - H00006919-R01 from Novus Biologicals
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MISSION® esiRNA - EHU094421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21120 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21120 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00384 from Sigma-Aldrich
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TCEA2 siRNA (Human) - CRH4742 from Cohesion Biosciences
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TFIIS RNAi - H00006919-R02 from Novus Biologicals
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TCEA2 - MBS8234740 from MyBioSource
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shRNA set against Human TCEA2 (NM_003195.4) - SHH424560 from Creative biogene
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shRNA set against Human TCEA2(NM_198723.1) - SHL060956 from Creative biogene
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shRNA set against Human TCEA2(NM_003195.4) - SHL060974 from Creative biogene
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TCEA2 shRNA Plasmid (Human) - CHH4742 from Cohesion Biosciences
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TCEA2 miRNA 3'UTR clone - MiUTR1H-10254 from Creative biogene
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TCEA2 miRNA 3'UTR clone - MiUTR1H-10255 from Creative biogene
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