MITF

Gene Symbol	MITF
Entrez Gene	4286
Alt Symbol	CMM8, MI, WS2, WS2A, bHLHe32
Species	Human
Gene Type	protein-coding
Description	microphthalmia-associated transcription factor
Other Description	class E basic helix-loop-helix protein 32
Swissprots	Q9P2Y8 B4DJL2 Q14841 E9PFN0 O75030 Q9P2V1 D3K197 Q9P2V0 Q9P2V2
Accessions	AAC39639 AIZ97493 BAA95206 BAA95207 BAA95208 BAA95209 EAW65479 EAW65480 EAW65481 EAW65482 EAW65483 EAW65484 O75030 AB006909 BAA32288 AB006988 BAB83926 AB006989 BAC16749 AB061771 BAB85121 AK291318 BAF84007 AK296129 BAG58874 AK297858 BAG60189 AL110195 CAB53672 AL117653 AW242257 AY632572 BC011461 BC012503 BC026961 AAH26961 BC065243 AAH65243 BM800230 BQ219650 BU167035 DA058963 DC388606 GU355676 ADB90411 Z29678 CAA82775 XM_005264754 XP_005264811 XM_005264755 XP_005264812 XM_006713164 XP_006713227 XM_011533722 XP_011532024 XM_011533723 XP_011532025 XM_011533724 XP_011532026 XM_011533725 XP_011532027 XM_011533726 XP_011532028 NM_000248 NP_000239 NM_001184967 NP_001171896 NM_001184968 NP_001171897 NM_006722 NP_006713 NM_198158 NP_937801 NM_198159 NP_937802 NM_198177 NP_937820 NM_198178 NP_937821
Function	Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378}.
Subcellular Location	Nucleus.
Tissue Specificity	Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines. {ECO:0000269|PubMed:20163701}.
Top Pathways	Melanoma, Melanogenesis, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SimpleChIP ® Human MITF Promoter Primers - 12377 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Mouse/Human Phospho-MITF (Ser180/73) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1189 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human MITF ELISA Kit (Cell-Based ELISA) - LS-F2149 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human MITF ELISA Kit (Sandwich ELISA) - LS-F8437 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Human MITF ELISA Kit - abx152343 from Abbexa Category ELISA Kit Sensitivity 0.059 ng/ml Range 0.156 ng/ml - 10 ng/ml

Microphthalmia Associated Transcription Factor (MITF), Human, ELISA Kit - SEH645Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.059ng/mL Range 0.156-10ng/mL

Microphthalmia-associated transcription factor, MITF, Human, ELISA Kit - E0547h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

MITF (Human) IP-WB Antibody Pair - H00004286-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

MITF Colorimetric Cell-Based ELISA Kit - CB5450 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

MITF (Phospho-Ser180/73) Colorimetric Cell-Based ELISA Kit - CBP1179 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human MITF(Microphthalmia Associated Transcription Factor) ELISA Kit - E-EL-H1644 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Microphthalmia Associated Transcription Factor (MITF), ELISA Kit - MBS2019067 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.059ng/mL. Range 0.156-10ng/mL

MITF, ELISA Kit - MBS2515907 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human MITF is 0.094ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.156-10ng/mL

ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) - SEH645Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) - SEH645Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rat MITF ELISA Kit (Custom ELISA) - LS-F14749 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human MITF ELISA Kit (Custom ELISA) - LS-F14750 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse MITF ELISA Kit (Custom ELISA) - LS-F14751 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human sTNF-1(Soluble Tumor Necrosis Factor 1) ELISA Kit - E-EL-H1644 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human Microphthalmia-associated transcription factor ELISA Kit - abx253903 from Abbexa Category ELISA Kit Range 0.625 ng/ml - 40 ng/ml

Human MITF ELISA Kit (Sandwich ELISA) - LS-F21146 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.094 ng/ml Range 0.156-10 ng/ml

Microphthalmia Associated Transcription Factor (MITF), Human, ELISA Kit - DL-MITF-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

MITF ELISA Kit - DEIA-XYA1212 from Creative Diagnostics Category ELISA Kit

MITF (Phospho-Ser180/73) ELISA Kit - DEIA-XYA1213 from Creative Diagnostics Category ELISA Kit

Microphthalmia Associated Transcription Factor, MITF, Human, ELISA Kit - E-EL-H1644 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Search more