| Gene Symbol |
Hemgn
|
| Entrez Gene |
113882
|
| Alt Symbol |
Edag-1, Edag1, Hgn, RP59
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
hemogen
|
| Other Description |
erythroid differentiation gene 1|hemopoietic gene protein
|
| Swissprots |
Q9ER23 Q6AZ54
|
| Accessions |
EDL98838 EDL98839 Q6AZ54 AJ302650 CAC16090 BC078739 AAH78739 FQ231115 FQ232586 XM_008763693 XP_008761915 XM_008763694 XP_008761916 NM_133294 NP_579828
|
| Function |
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed by bone marrow cells and osteoblasts. Also expressed by ameloblasts in tooth enamel (at protein level). Expressed in enamel organ, ameloblasts, spleen, bone marrow cells and osteoblasts. {ECO:0000269|PubMed:11161722, ECO:0000269|PubMed:11891990, ECO:0000269|PubMed:15726423}.
|
