| Gene Symbol | Hemgn |
|---|---|
| Entrez Gene | 113882 |
| Alt Symbol | Edag-1, Edag1, Hgn, RP59 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | hemogen |
| Other Description | erythroid differentiation gene 1|hemopoietic gene protein |
| Swissprots | Q9ER23 Q6AZ54 |
| Accessions | EDL98838 EDL98839 Q6AZ54 AJ302650 CAC16090 BC078739 AAH78739 FQ231115 FQ232586 XM_008763693 XP_008761915 XM_008763694 XP_008761916 NM_133294 NP_579828 |
| Function | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Tissue Specificity | Expressed by bone marrow cells and osteoblasts. Also expressed by ameloblasts in tooth enamel (at protein level). Expressed in enamel organ, ameloblasts, spleen, bone marrow cells and osteoblasts. {ECO:0000269|PubMed:11161722, ECO:0000269|PubMed:11891990, ECO:0000269|PubMed:15726423}. |
CompoZr® Knockout ZFN Kit - CKOZFN54988 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND54988 from Sigma-Aldrich
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HEMGN siRNA (Rat) - CRR2758 from Cohesion Biosciences
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HEMGN - MBS8200236 from MyBioSource
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shRNA set against Rat HEMGN (NM_133294.1) - SHH311497 from Creative biogene
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shRNA set against Rat Hemgn(NM_133294.1) - SHH118165 from Creative biogene
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Rat HEMGN siRNA - orb297607 from Biorbyt
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HEMGN shRNA Plasmid (Rat) - CHR2758 from Cohesion Biosciences
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HEMGN miRNA 3'UTR clone - MiUTR1R-02414 from Creative biogene
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