CHST2

Gene Symbol	CHST2
Entrez Gene	9435
Alt Symbol	C6ST, GST-2, GST2, Gn6ST-1, HEL-S-75, glcNAc6ST-1
Species	Human
Gene Type	protein-coding
Description	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
Other Description	N-acetylglucosamine 6-O-sulfotransferase 1|carbohydrate (chondroitin 6/keratan) sulfotransferase 2|carbohydrate sulfotransferase 2|epididymis secretory protein Li 75|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2
Swissprots	Q9UED5 Q2M370 Q9Y4C5 D3DNG5 Q9Y6F2 Q9GZN5
Accessions	BAB16887 EAW78952 EAW78953 Q9Y4C5 AB014679 BAA34265 AB014680 BAA34266 AB021124 BAB16886 AF083066 AAD20981 AK023268 BAG51179 BC017499 BC036930 BC042160 BC068604 BC105010 AAI05011 BC105012 AAI05013 BX387933 CA431595 EU668328 ACF94481 EU832159 ACE87509 EU832253 ACE86823 NM_004267 NP_004258
Function	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:11042394}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}.
Tissue Specificity	Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:10049591, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9722682}.
Top Pathways	Glycosaminoglycan biosynthesis - keratan sulfate

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CHST2 protein fragment - ab160485 from Abcam Category Protein Source Wheat germ Species Human

CHST2 Antibody Blocking Peptide - LS-E424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHST2 Antibody Blocking Peptide - LS-E16926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHST2 Antibody Blocking Peptide - LS-E16925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHST2 Antibody Blocking Peptide - LS-E6526 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Carbohydrate Sulfotransferase 2/CHST2 Protein - H00009435-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CHST2-Antibody-Center-Blocking-peptide - BP10704c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHST2-Antibody-C-term-Blocking-Peptide - BP19294b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CHST2, CF - 5107-ST-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Tyr76-Leu530, with an N-terminal 5-His tag

CHST2 peptide - orb218254 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

Chst2 Blocking Peptide - 33R-9537 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHST2 Blocking Peptide - 33R-6649 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHST2 Blocking Peptide - abx063585 from Abbexa Category Peptide Species Human

CHST2 - H00009435-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CHST2 - H00009435-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHST2 fusion protein - Ag23293 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CHST2 Blocking Peptide - CBP2391 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human Carbohydrate sulfotransferase 2(CHST2) - CSB-YP897281HU CSB-EP897281HU CSB-BP897281HU CSB-MP897281HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CHST2 Protein, CF - 5107-ST from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source Chinese Hamster Ovary cell line, CHO-derived Tyr76-Leu530, with an N-terminal 5-His tag Species Human

Carbohydrate sulfotransferase 2 (CHST2), Recombinant Protein - MBS1380156 from MyBioSource Category Protein Prices $780.00, $780.00, $1,005.00, $1,005.00, $1,085.00, $1,085.00, $1,540.00, $1,540.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CHST2 Peptide, Human - M34GP03151H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human CHST2 Protein, CF - 5107-ST from Novus Biologicals Category Protein Prices $329.00 Sizes 20 µg Species Human

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