CHST2

Gene Symbol CHST2
Entrez Gene 9435
Alt Symbol C6ST, GST-2, GST2, Gn6ST-1, HEL-S-75, glcNAc6ST-1
Species Human
Gene Type protein-coding
Description carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
Other Description N-acetylglucosamine 6-O-sulfotransferase 1|carbohydrate (chondroitin 6/keratan) sulfotransferase 2|carbohydrate sulfotransferase 2|epididymis secretory protein Li 75|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2
Swissprots Q9UED5 Q2M370 Q9Y4C5 D3DNG5 Q9Y6F2 Q9GZN5
Accessions BAB16887 EAW78952 EAW78953 Q9Y4C5 AB014679 BAA34265 AB014680 BAA34266 AB021124 BAB16886 AF083066 AAD20981 AK023268 BAG51179 BC017499 BC036930 BC042160 BC068604 BC105010 AAI05011 BC105012 AAI05013 BX387933 CA431595 EU668328 ACF94481 EU832159 ACE87509 EU832253 ACE86823 NM_004267 NP_004258
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. {ECO:0000269|PubMed:11042394}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}; Single-pass type II membrane protein {ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:22260995}.
Tissue Specificity Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. {ECO:0000269|PubMed:10049591, ECO:0000269|PubMed:11310842, ECO:0000269|PubMed:9722682}.
Top Pathways Glycosaminoglycan biosynthesis - keratan sulfate

CHST2 CRISPR/Cas9 KO Plasmid (h) - sc-411281 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 HDR Plasmid (h) - sc-411281-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 Double Nickase Plasmid (h) - sc-411281-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 Double Nickase Plasmid (h2) - sc-411281-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 CRISPR Activation Plasmid (h) - sc-411281-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 CRISPR Activation Plasmid (h2) - sc-411281-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 Lentiviral Activation Particles (h) - sc-411281-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 Lentiviral Activation Particles (h2) - sc-411281-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHST2 siRNA (h) - sc-62116 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHST2 shRNA Plasmid (h) - sc-62116-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHST2 shRNA (h) Lentiviral Particles - sc-62116-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Carbohydrate Sulfotransferase 2/CHST2 RNAi - H00009435-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6110 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6110 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHST2 siRNA (Human) - CRH6255 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHST2 - MBS8212507 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human CHST2 siRNA - orb266757 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHST2 shRNA Plasmid (Human) - CHH6255 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CHST2 miRNA 3'UTR clone - MiUTR3H-06281 from Creative biogene

Species Reactivities Human
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