| Gene Symbol |
IRF7
|
| Entrez Gene |
3665
|
| Alt Symbol |
IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon regulatory factor 7
|
| Other Description |
IRF-7|interferon regulatory factor-7H
|
| Swissprots |
Q9UE79 O00332 Q92985 B9EGL3 O00331 O75924 O00333
|
| Accessions |
AAG30003 EAX02355 EAX02356 EAX02357 EAX02358 EAX02359 EAX02360 Q92985 AF076494 AAC70999 AK303752 BAG64723 BC136555 AAI36556 BC144242 BM849172 DA601567 DA967682 KC477210 AGI78456 U53830 AAB80686 U53831 AAB80688 U53832 AAB80690 U73036 AAB17190 XM_005252906 XP_005252963 XM_005252907 XP_005252964 XM_005252908 XP_005252965 XM_005252909 XP_005252966 XM_006725137 XP_006725200 XM_006725138 XP_006725201 XM_006725139 XP_006725202 XM_011520066 XP_011518368 NM_001572 NP_001563 NM_004029 NP_004020 NM_004031 NP_004022 NM_004030
|
| Function |
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear locali
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
|
| Tissue Specificity |
Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
|
| Top Pathways |
Hepatitis C, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Measles, Influenza A
|