IRF7

Gene Symbol IRF7
Entrez Gene 3665
Alt Symbol IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H
Species Human
Gene Type protein-coding
Description interferon regulatory factor 7
Other Description IRF-7|interferon regulatory factor-7H
Swissprots Q9UE79 O00332 Q92985 B9EGL3 O00331 O75924 O00333
Accessions AAG30003 EAX02355 EAX02356 EAX02357 EAX02358 EAX02359 EAX02360 Q92985 AF076494 AAC70999 AK303752 BAG64723 BC136555 AAI36556 BC144242 BM849172 DA601567 DA967682 KC477210 AGI78456 U53830 AAB80686 U53831 AAB80688 U53832 AAB80690 U73036 AAB17190 XM_005252906 XP_005252963 XM_005252907 XP_005252964 XM_005252908 XP_005252965 XM_005252909 XP_005252966 XM_006725137 XP_006725200 XM_006725138 XP_006725201 XM_006725139 XP_006725202 XM_011520066 XP_011518368 NM_001572 NP_001563 NM_004029 NP_004020 NM_004031 NP_004022 NM_004030
Function Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear locali
Subcellular Location Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Tissue Specificity Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
Top Pathways Hepatitis C, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Measles, Influenza A

Phospho-IRF-7 (Ser471/472) Antibody - 5184 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, mock transfected or transfected with IKKε and/or IRF-7, using Phospho-IRF-7 (Ser471/472) Antibody (upper) or IRF-7 Antibody #4920 (lower).

Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb - 12390 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7E1W
Western blot analysis of extracts from HT-29 cells, untreated or treated with Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml, overnight) followed by transfection with poly(I:C) (2.5 μg/ml, 7 hr), as indicated, using Phospho-IRF-7 (Ser477) (D7E1W) Rabbit mAb (upper), IRF-7 Antibody #4920 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).

IRF-7 (D2A1J) Rabbit mAb - 13014 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2A1J
Western blot analysis of extracts from HT-29 and G-361 cells, untreated (-) or treated with Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml, overnight; +), using IRF-7 (D2A1J) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

IRF-7 Antibody - 4920 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells treated with IFN-α (100 nM) for the indicated times, using IRF-7 Antibody.

IRF-7 (F-1) - sc-74471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRF-7 (F-1): sc-74471. Western blot analysis of IRF-7 expression in Jurkat (A), PMA-treated Jurkat (B) and Raji (C) whole cell lysates.

IRF-7 (C-20) - sc-15994 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IRF-7 (G-8) - sc-74472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRF-7 (G-8): sc-74472. Western blot analysis of IRF-7 expression in Jurkat (A), PMA-treated Jurkat (B), HuT 78 (C) and Raji (D) whole cell lysates.

IRF-7 (H-246) - sc-9083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRF-7 (H-246): sc-9083. Immunofluorescence staining of methanol-fixed HeLa cells showing nucleolar and nuclear localization.

IRF-7 (Y-19) - sc-15993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IRF-7 (3D9) - sc-130509 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
IRF-7 (3D9): sc-130509. Western blot analysis of IRF-7 expression in Jurkat whole cell lysate.

Anti-IRF7 antibody - ab62505 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab62505 stained HepG2 cells (ab7900). The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum (ab7481) / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab62505, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-IRF7 antibody - ab115352 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115352, at 5 µg/ml, staining IRF7 in formalin-fixed, paraffin-embedded Human Spleen tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-IRF7 antibody [3D9] - ab70069 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D9
Anti-IRF7 antibody [3D9] (ab70069) at 1/1000 dilution + Jurkat cell lysates at 40 µgSecondaryGoat anti-mouse secondary antibody conjugated to HRPdeveloped using the ECL technique

Anti-IRF7 antibody [EPR4718] - ab109255 from Abcam

Prices $403.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4718
All lanes : Anti-IRF7 antibody [EPR4718] (ab109255) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : Raji cell lysateLane 3 : HuT78 cell lysateLane 4 : RAW264.7 cell lysateLysates/proteins at 10 µg per lane.

Anti-IRF7 antibody - C-terminal - ab189305 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thymus tissue, labeling IRF7 using ab189305 at 5 µg/ml.

Anti-IRF7 Antibody (aa1-150, clone 3D9) IHC-plus™ - LS-B2945 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D9
Anti-IRF7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2945 concentration 20 ug/ml.

Anti-IRF7 Antibody (Internal, clone EPR4718) IHC-plus™ - LS-B6550 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4718
Anti-IRF7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6550 dilution 1:100.

Anti-IRF7 Antibody (Internal) IHC-plus™ - LS-B1372 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IRF7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1372 concentration 5 ug/ml.

Anti-IRF7 Antibody (C-Terminus) IHC-plus™ - LS-B577 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IRF7 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B577 concentration 5 ug/ml.

Anti-IRF7 Antibody (aa463-477) - LS-C70831 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IRF7 Antibody (aa35-84) - LS-C110267 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IRF7 antibody LS-C110267 Western blot of HeLa lysate.

Anti-IRF7 Antibody (C-Terminus) - LS-C110268 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IRF7 antibody LS-C110268 Western blot of HT1080 cell lysate.

IRF7 Antibody - NBP1-77263 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IRF7 Antibody [NBP1-77263] - 293 whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 ug/ml.

IRF7 Antibody - NBP1-77264 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IRF7 Antibody [NBP1-77264] - 293 whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 ug/ml.

IRF7 Antibody - NBP1-02718 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IRF7 Antibody [NBP1-02718] - Whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 ug/ml.
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